ArticleScience advances2018
Neuronal noise as an origin of sleep arousals and its role in sudden infant death syndrome.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed.
- Evaluating in-vivo spontaneous firing rate in the brain based on neuronal noise modeling.Communications biology · 2025Article
- Role of the Locus Coeruleus Arousal Promoting Neurons in Maintaining Brain Criticality across the Sleep-Wake Cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mechanistic description of spontaneous loss of memory persistent activity based on neuronal synaptic strength.Heliyon · 2024Article
- The constrained-disorder principle defines the functions of systems in nature.Frontiers in network physiology · 2024Review
- Application of short-term analysis of skin temperature variability in prediction of survival in patients with cirrhosis.Frontiers in network physiology · 2023Article
- Sleep and Breathing Disturbances in Children With Leigh Syndrome: A Comparative Study.Pediatric neurology · 2022Article
- Ensemble of coupling forms and networks among brain rhythms as function of states and cognition.Communications biology · 2022Article
- A Novel Quantitative Arousal-Associated EEG-Metric to Predict Severity of Respiratory Distress in Obstructive Sleep Apnea Patients.Frontiers in physiology · 2022Article
- Hyperthermia and Heat Stress as Risk Factors for Sudden Infant Death Syndrome: A Narrative Review.Frontiers in pediatrics · 2022Review
- Sleep as a random walk: a super-statistical analysis of EEG data across sleep stages.Communications biology · 2021Article
- Article
- The New Field of Network Physiology: Building the Human Physiolome.Frontiers in network physiology · 2021Article
- Characterization of lung-to-finger circulation time in sleep study assessment: the Multi-Ethnic Study of Atherosclerosis.Physiological measurement · 2020Article
- Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture.PLoS computational biology · 2019Article
- The avalanche-like behaviour of large-scale haemodynamic activity from wakefulness to deep sleep.Journal of the Royal Society, Interface · 2019Article
- A Biased Diffusion Approach to Sleep Dynamics Reveals Neuronal Characteristics.Biophysical journal · 2019Article
- Heart Rhythm Analyzed via Shapelets Distinguishes Sleep From Awake.Frontiers in physiology · 2019Article
- Multi-Scale Expressions of One Optimal State Regulated by Dopamine in the Prefrontal Cortex.Frontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In addition to regular sleep/wake cycles, humans and animals exhibit brief arousals from sleep. Although much is known about consolidated sleep and wakefulness, the mechanism that triggers arousals remains enigmatic. Here, we argue that arousals are caused by the intrinsic neuronal noise of wake-promoting neurons. We propose a model that simulates the superposition of the noise from a group of neurons, and show that, occasionally, the superposed noise exceeds the excitability threshold and provokes an arousal. Because neuronal noise decreases with increasing temperature, our model predicts arousal frequency to decrease as well. To test this prediction, we perform experiments on the sleep/wake behavior of zebrafish larvae and find that increasing water temperatures lead to fewer and shorter arousals, as predicted by our analytic derivations and model simulations. Our findings indicate a previously unrecognized neurophysiological mechanism that links sleep arousals with temperature regulation, and may explain the origin of the clinically observed higher risk for sudden infant death syndrome with increased ambient temperature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.