Evidence map›Paper›PMID 29707619›Full record

ArticleTransplantation direct2018

Differences in Proinflammatory Cytokines and Monocyte Subtypes in Older as Compared With Younger Kidney Transplant Recipients.

Emily C Liang, Maura Rossetti, Tiffany Sidwell, Victoria Groysberg, Gema Sunga, Yael Korin, Sitaram Vangala, Basmah Abdalla, Erik Lum, Suphamai Bunnapradist and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Emily C LiangDivision of Infectious Diseases, Department of Medicine, University of California Los Angeles Immunogenetics Center, Los Angeles, CA.
Maura RossettiDepartment of Pathology and Laboratory Medicine, University of California Los Angeles Immunogenetics Center, Los Angeles, CA.
Tiffany SidwellDepartment of Pathology and Laboratory Medicine, University of California Los Angeles Immunogenetics Center, Los Angeles, CA.
Victoria GroysbergDepartment of Pathology and Laboratory Medicine, University of California Los Angeles Immunogenetics Center, Los Angeles, CA.
Gema SungaDepartment of Pathology and Laboratory Medicine, University of California Los Angeles Immunogenetics Center, Los Angeles, CA.
Yael KorinDepartment of Pathology and Laboratory Medicine, University of California Los Angeles Immunogenetics Center, Los Angeles, CA.
Sitaram VangalaDepartment of Medicine Statistics Core, University of California Los Angeles, Los Angeles, CA.
Basmah AbdallaDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA.
Erik LumDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA.
Suphamai BunnapradistDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA.
Phuong-Thu PhamDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA.
Gabriel DanovitchDivision of Nephrology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California Los Angeles Immunogenetics Center, Los Angeles, CA.
Joanna SchaenmanDivision of Infectious Diseases, Department of Medicine, University of California Los Angeles Immunogenetics Center, Los Angeles, CA.
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Evaluation of T Cell Immune Function Impairment in Elderly Solid Organ Transplant RecipientsR03AG050946 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHAENMAN, JOANNA M · 2015 to 2016
$231k
NCATS NIH HHS UL1 TR001881NIA NIH HHS R03 AG050946
6 · The paper itself

Abstract

backgroundThe number of elderly patients with end-stage kidney disease requiring kidney transplantation continues to grow. Evaluation of healthy older adults has revealed proinflammatory changes in the immune system, which are posited to contribute to age-associated illnesses via "inflamm-aging." Immunologic dysfunction is also associated with impaired control of infections. Whether these immunologic changes are found in older kidney transplant recipients is not currently known, but may have important implications for risk for adverse clinical outcomes.

methodsThree months after transplant, innate immune phenotype was evaluated by flow cytometry from 60 kidney transplant recipients (22 older [≥60 years] and 38 younger [<60 years old]). Multiplex cytokine testing was used to evaluate plasma cytokine levels. Younger patients were matched to older patients based on transplant type and induction immune suppression.

resultsOlder kidney transplant recipients demonstrated decreased frequency of intermediate monocytes (CD14++CD16+) compared with younger patients (1.2% vs 3.3%,

conclusionsIn this pilot study of kidney transplant recipients, we identified differences in the innate immune system in older as compared with younger patients, including increased levels of IFN-γ. This suggests that age-associated nonspecific inflammation persists despite immune suppression. The ability to apply noninvasive testing to transplant recipients will provide tools for patient risk stratification and individualization of immune suppression regimens to improve outcomes after transplantation.

Identifiers

PMID29707619
PMCPMC5912018
OpenAlexW2792052079

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.