Evidence map›Paper›PMID 29707599›Full record

ArticleOpen forum infectious diseases2018

Prevalence and Evolution of Renal Impairment in People Living With HIV in Rural Tanzania.

Herry Mapesi, Aneth V Kalinjuma, Alphonce Ngerecha, Fabian Franzeck, Christoph Hatz, Marcel Tanner, Michael Mayr, Hansjakob Furrer, Manuel Battegay, Emilio Letang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Herry MapesiIfakara Branch, Ifakara Health Institute, Ifakara, Tanzania.
Aneth V KalinjumaIfakara Branch, Ifakara Health Institute, Ifakara, Tanzania.
Alphonce NgerechaBugando Medical Centre, Mwanza, Tanzania.
Fabian FranzeckDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
Christoph HatzSwiss Tropical and Public Health Institute, Basel, Switzerland.
Marcel TannerSwiss Tropical and Public Health Institute, Basel, Switzerland.
Michael MayrDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
Hansjakob FurrerDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
Manuel BattegayUniversity of Basel, Basel, Switzerland.
Emilio LetangIfakara Branch, Ifakara Health Institute, Ifakara, Tanzania.
Maja WeisserIfakara Branch, Ifakara Health Institute, Ifakara, Tanzania.
Tracy R GlassSwiss Tropical and Public Health Institute, Basel, Switzerland.
KIULARCO Study Group
Ifakara Health Institute · TZSwiss Tropical and Public Health Institute · CHUniversity of Basel · CHUniversity of Bern · CHUniversity Hospital of Basel · CHBugando Medical Centre · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe assessed the prevalence, incidence, and predictors of renal impairment among people living with HIV (PLWHIV) in rural Tanzania.

methodsIn a cohort of PLWHIV aged ≥15 years enrolled from January 2013 to June 2016, we assessed the association between renal impairment (estimated glomerural filtration rate < 90 mL/min/1.73 m

resultsOf 1093 PLWHIV, 172 (15.7%) had renal impairment at enrollment. Of 921 patients with normal renal function at baseline, 117 (12.7%) developed renal impairment during a median follow-up (interquartile range) of 6.2 (0.4-14.7) months. The incidence of renal impairment was 110 cases per 1000 person-years (95% confidence interval [CI], 92-132). At enrollment, logistic regression identified older age (adjusted odds ratio [aOR], 1.79; 95% CI, 1.52-2.11), hypertension (aOR, 1.84; 95% CI, 1.08-3.15), CD4 count <200 cells/mm

conclusionsOur study found a low prevalence of renal impairment among PLWHIV despite high usage of tenofovir and its association with age, hypertension, low CD4 count, and advanced WHO stage. These important and reassuring safety data stress the significance of noncommunicable disease surveillance in aging HIV populations in sub-Saharan Africa.

Indexed as

HIVrenal impairmentsub-Saharan Africa

Identifiers

PMID29707599
PMCPMC5912087
OpenAlexW2795582667

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.