Trial reportBioMed research international2018
Cognitive Behavior Therapy as Augmentation for Sertraline in Treating Patients with Persistent Postural-Perceptual Dizziness.
Trial report in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Effectiveness of Telerehabilitation in Dizziness: A Systematic Review with Meta-Analysis.Sensors (Basel, Switzerland) · 2024Pooled it
- Non-pharmacological interventions for persistent postural-perceptual dizziness (PPPD).The Cochrane database of systematic reviews · 2023Pooled it
- Pharmacological interventions for persistent postural-perceptual dizziness (PPPD).The Cochrane database of systematic reviews · 2023Pooled it
- [Application of computerized cognitive behavioral therapy in patients with persistent postural-perceptual dizziness].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Trial
- Treatment of Functional Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Anxiety-Related Functional Dizziness: A Systematic Review of the Recent Evidence on Vestibular, Cognitive Behavioral, and Integrative Therapies.Life (Basel, Switzerland) · 2026Review
- Neurotransmitter regulatory networks in persistent postural-perceptual dizziness: potential mechanisms and therapeutic implications.Frontiers in neurology · 2026Review
- The effect of combined cognitive behavioral therapy and rehabilitation training on negative emotions of patients with vestibular dysfunction: a real-world cohort study.Frontiers in public health · 2026Article
- Review
- Diagnostics and Group Therapy in Patients with Persistent Postural-Perceptual Dizziness and Anxiety Disorder: Biomarkers and Neurofunctional Correlates of Underlying Treatment Effects.Diagnostics (Basel, Switzerland) · 2025Article
- Long-term outcomes of pharmacotherapy in patients with persistent postural-perceptual dizziness.Frontiers in neurology · 2025Article
- Research Progress on the Potential Pathogenesis of Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Review
- Clinical characteristics of persistent postural-perceptual dizziness and its visual subtype in Korean patients: A multicenter cross-sectional study.Brain and behavior · 2024Article
- Comparative effectiveness of non- pharmacological treatments in patients with persistent postural-perceptual dizziness: a systematic review and effect sizes analyses.Frontiers in neurology · 2024Review
- Biobehavioral approach to distinguishing panic symptoms from medical illness.Frontiers in psychiatry · 2024Review
- Migraine management for the otolaryngologist.Laryngoscope investigative otolaryngology · 2023Review
- [Research progress on the questionnaire related to persistent postural-perceptual dizziness].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Review
- Effect of Fluoxetine and Acacetin on Central Vestibular Compensation in an Animal Model of Unilateral Peripheral Vestibulopathy.Biomedicines · 2022Article
- Functional neurological disorder: new subtypes and shared mechanisms.The Lancet. Neurology · 2022Review
- A Randomized, Double-Blind, Sham-Controlled Trial of Transcranial Direct Current Stimulation for the Treatment of Persistent Postural-Perceptual Dizziness (PPPD).Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent postural-perceptual dizziness (PPPD) is a common vestibular disorder. This study was conducted to assess whether the addition of cognitive behavior therapy (CBT) could significantly improve the efficacy and acceptability of sertraline in treating PPPD.
methodsPPPD patients were recruited and randomly assigned to control and experiment groups. Patients in both groups received sertraline 50-200 mg/day, and only patients in the experiment group received CBT (twice a week, one hour per time). The treatment was continued for eight weeks. At baseline, week 2, week 4, and week 8, the 25-item Dizziness Handicap Inventory (DHI), Hamilton Anxiety Rating Scale (HARS), and Hamilton Depression Rating Scale (HDRS) were used to assess the self-perceived handicapping effects caused by PPPD, anxiety, and depressive symptoms, respectively. The dose of sertraline used and the adverse events in both groups were recorded and analyzed.
resultsIn total, 91 PPPD patients were randomly assigned to the control group (
conclusionThese results demonstrated that the addition of CBT could significantly improve the efficacy and acceptability of sertraline in treating PPPD and reduce the dose of sertraline used.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.