ReviewAnnals of cardiothoracic surgery2018
A reassessment of tracheal substitutes-a systematic review.
Review in Annals of cardiothoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Feasibility and outcomes of long-segment tracheal replacement with biological and engineered scaffolds.General thoracic and cardiovascular surgery · 2026Review
- Use of a composite, 3D-printed patch as a partial airway replacement: A pilot study on the porcine model.Bioengineering & translational medicine · 2026Article
- Preclinical and human tracheal replacement with aortic grafts: a narrative review.Mediastinum (Hong Kong, China) · 2026Review
- Decellularized extracellular matrix-loaded exosome hydrogel for cell-free tracheal scaffold in tracheal defect reconstruction and repair.Journal of nanobiotechnology · 2025Article
- Circumferential tracheal replacement with silicone stent supported, cryopreserved aortic homograft.Journal of surgical case reports · 2024Article
- Synergistic Effects of SDS and HInternational journal of biomaterials · 2024Article
- Biomimetic in situ tracheal microvascularization for segmental tracheal reconstruction in one-step.Bioengineering & translational medicine · 2023Article
- Comparison of the biological properties between 3D-printed and decellularized tracheal grafts.Bioprocess and biosystems engineering · 2023Article
- Article
- Novel Therapy for Acquired Tracheomalacia with a Tissue-Engineered Extraluminal Tracheal Splint and Autologous Mesenchymal-Derived Chondrocytes.International archives of otorhinolaryngology · 2023Article
- Development of tissue-engineered tracheal scaffold with refined mechanical properties and vascularisation for tracheal regeneration.Frontiers in bioengineering and biotechnology · 2023Article
- Reconstruction of the trachea and carina: Surgical reconstruction, autologous tissue transplantation, allograft transplantation, and bioengineering.Thoracic cancer · 2022Review
- Enhancing Stem Cell-Based Therapeutic Potential by Combining Various Bioengineering Technologies.Frontiers in cell and developmental biology · 2022Review
- The Growing Medical Need for Tracheal Replacement: Reconstructive Strategies Should Overcome Their Limits.Frontiers in bioengineering and biotechnology · 2022Review
- Partial Decellularized Scaffold Combined with Autologous Nasal Epithelial Cell Sheet for Tracheal Tissue Engineering.International journal of molecular sciences · 2021Article
- Preventing Biofilm Formation and Development on Ear, Nose and Throat Medical Devices.Biomedicines · 2021Review
- Partial Decellularization for Segmental Tracheal Scaffold Tissue Engineering: A Preliminary Study in Rabbits.Biomolecules · 2021Article
- Experimental Tracheal Replacement: Angiogenesis and Null Apoptosis Promote Stenosis.Journal of chest surgery · 2021Article
- 3D Printed Biomimetic PCL Scaffold as Framework Interspersed With Collagen for Long Segment Tracheal Replacement.Frontiers in cell and developmental biology · 2021Article
- Standardization of Microcomputed Tomography for Tracheal Tissue Engineering Analysis.Tissue engineering. Part C, Methods · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTracheal substitutes remain an active area of research. For rare patients with large or complex defects that cannot be repaired primarily, replacement of the airway may represent the only treatment option. The present systematic review aims to assess the clinical successes and setbacks of current methods of airway replacement.
methodsSystematic review using Medline and PubMed from 01 January 2000 to 01 October 2017 focusing on clinical translation of circumferential or near circumferential (>270°) tracheal substitutes. Studies were identified using key phrases including terms such as "tracheal replacement", "tracheal regeneration", "tracheal transplant", "tracheal tissue engineering", and "tracheal substitution". Animal or non-clinical studies were excluded. Reviews were included if they contained clinical updates.
resultsTwenty-one studies were included in assessment comprising a mix of case reports, case studies, and a single review with clinical updates on prior studies. Since 2001, 41 patients have undergone a reported circumferential or near circumferential tracheal substitution through four underlying methodologies including allotransplantation, autologous tissue reconstruction, bioprosthetic reconstruction, and tissue engineered reconstruction. Each modality has unique advantages and disadvantages with varying success in clinical application.
conclusionsThe need for tracheal substitution remains a difficult clinical problem without an ideal prosthetic or graft material. While various modalities have had limited clinical success, further laboratory work is necessary before tracheal substitutes can become widely adopted, especially in the case of tissue engineered conduits, which have been setback by premature clinical translation.
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