Evidence map›Paper›PMID 29707441›Full record

ArticlePlastic and reconstructive surgery. Global open2018

Genetic Requirement of

Kana Ishii, Kusumika Mukherjee, Takashi Okada, Eric C Liao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Functional and Genetic Analyses Unveil the Implication ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kana IshiiDivision of Plastic and Reconstructive Surgery, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Mass.; Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan; and Harvard Medical School, Harvard University, Boston, Mass.
Kusumika MukherjeeDivision of Plastic and Reconstructive Surgery, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Mass.; Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan; and Harvard Medical School, Harvard University, Boston, Mass.
Takashi OkadaDivision of Plastic and Reconstructive Surgery, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Mass.; Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan; and Harvard Medical School, Harvard University, Boston, Mass.
Eric C LiaoDivision of Plastic and Reconstructive Surgery, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Mass.; Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan; and Harvard Medical School, Harvard University, Boston, Mass.
Harvard University · USNippon Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCraniofacial malformations are among the most common congenital anomalies. Cranial neural crest cells (CNCCs) form craniofacial structures involving multiple cellular processes, perturbations of which contribute to craniofacial malformations. Adhesion of cells to the extracellular matrix mediates bidirectional interactions of the cells with their extracellular environment that plays an important role in craniofacial morphogenesis. Talin (tln) is crucial in cell-matrix adhesion between cells, but its role in craniofacial morphogenesis is poorly understood.

methodsTalin gene expression was determined by whole mount in situ hybridization. Craniofacial cartilage and muscles were analyzed by Alcian blue in Tg(mylz2:mCherry) and by transmission electron microscopy. Pulse-chase photoconversion, 5-ethynyl-2'-deoxyuridine proliferation, migration, and apoptosis assays were performed for functional analysis.

resultsExpression of

conclusionsThe work shows that

Identifiers

PMID29707441
PMCPMC5908504
OpenAlexW2791143658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.