ArticleBone research2018
Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.
Article in Bone research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
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- Application of Nuclear Medicine Techniques in Musculoskeletal Infection: Current Trends and Future Prospects.Journal of clinical medicine · 2024Review
- In Vivo Detection ofInternational journal of biomedical imaging · 2024Article
- Recent Advancements in Radiopharmaceuticals for Infection Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [Journal of the American Chemical Society · 2023Article
- Radiometal chelators for infection diagnostics.Frontiers in nuclear medicine · 2023Article
- Antibacterial intraosseous implant surface coating that responds to changes in the bacterial microenvironment.Frontiers in bioengineering and biotechnology · 2022Article
- Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives.Frontiers in medicine · 2022Review
- PET/CT Imaging for Personalized Management of Infectious Diseases.Journal of personalized medicine · 2021Review
- Recent Progress in the Molecular Imaging of Tumor-Treating Bacteria.Nuclear medicine and molecular imaging · 2021Review
- Development of anFrontiers in immunology · 2021Article
- Current Clinical Methods for Detection of Peri-Prosthetic Joint Infection.Surgical infections · 2020Review
- Evaluation of Peptide-Based Probes towardACS infectious diseases · 2020Article
- Small Molecule Sensors Targeting the Bacterial Cell Wall.ACS infectious diseases · 2020Review
- [Advances in clinical diagnosis and treatment of chronic osteomyelitis in adults].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Review
- ImmunoPET: Concept, Design, and Applications.Chemical reviews · 2020Review
- Diagnosis and management of implant debris-associated inflammation.Expert review of medical devices · 2020Review
- Radiochemical Approaches to Imaging Bacterial Infections: Intracellular versus Extracellular Targets.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody (mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid (LTA). Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immunoPET imaging in an in vivo mouse model of prosthetic joint infection (PJI). In vitro and ex vivo binding of the anti-LTA mAb to pathogenic bacteria was measured with Octet, ELISA, and flow cytometry. The in vivo PJI mouse model was assessed using traditional imaging modalities, including positron emission tomography (PET) with [
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.