ArticleJournal of thoracic disease2018
Early changes in coagulation profiles and lactate levels in patients with septic shock undergoing extracorporeal membrane oxygenation.
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Prognostic models for mortality risk in patients requiring ECMO.Intensive care medicine · 2023Pooled it
- Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysis.Critical care (London, England) · 2021Pooled it
- Antithrombin III at admission as a new predictive factors for mortality in ECMO for cardiogenic shock caused by acute myocardial infarction.Scientific reports · 2026Article
- Biomarkers of multi-organ dysfunction in ECMO: prognostic signposts for palliative transitions.Frontiers in medicine · 2026Review
- Overt disseminated intravascular coagulation and antithrombin III predict bleeding and in-hospital mortality in patients undergoing extracorporeal membrane oxygenation.Frontiers in medicine · 2024Article
- Extracorporeal membrane oxygenation in adult patients with sepsis and septic shock: Why, how, when, and for whom.Journal of intensive medicine · 2024Review
- Editorial on Paper Titled Comparison of Veno-Arterial Extracorporeal Membrane Oxygenation Type in Patients Listed for Heart Transplantation.Korean circulation journal · 2023Article
- Different characteristics of bloodstream infection during venoarterial and venovenous extracorporeal membrane oxygenation in adult patients.Scientific reports · 2021Article
- Thrombosis and Coagulopathy in COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- Venoarterial Extracorporeal Membrane Oxygenation for Severe Neonatal Acute Respiratory Distress Syndrome in a Developing Country.Frontiers in pediatrics · 2020Article
- Article
- Clinical complications during veno-arterial extracorporeal membrane oxigenation in post-cardiotomy and non post-cardiotomy shock: still the achille's heel.Journal of thoracic disease · 2018Review
- Current Understanding of How Extracorporeal Membrane Oxygenators Activate Haemostasis and Other Blood Components.Frontiers in medicine · 2018Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the impact of coagulation profiles and lactate levels in patients with septic shock undergoing extracorporeal membrane oxygenation (ECMO).
methodsA retrospective analysis of coagulation profiles, including disseminated intravascular coagulation (DIC) score, before and during 48 h of ECMO support [on day 0 (pre-ECMO), day 1, and day 2], was conducted in patients with septic shock undergoing ECMO.
resultsA total of 37 patients were included, and 15 (40.5%) patients survived. The initial DIC scores did not change in either the pre-ECMO overt-DIC (n=15) or non-overt-DIC (n=22) group after ECMO commencement. However, the DIC scores were significantly higher, at all three time-points, in non-survivors than in survivors. Additionally, the lactate levels improved considerably in the pre-ECMO non-overt-DIC group and in survivors during ECMO support, but not in the pre-ECMO overt DIC group or non-survivors. On a multivariate analysis, the pre-ECMO DIC score was significantly associated with hospital death [odds ratio (OR), 3.935; 95% confidence interval (CI), 1.170-13.230]. Receiver operating characteristic (ROC) curves revealed that the combination of pre-ECMO DIC score plus lactate level was the best predictor of hospital death (area under the curve, 0.879; 0.771-0.987); patients with combined scores >9.35 (the optimal cut-off) exhibited a three-fold higher mortality rate than did those with lower scores (81.8%
conclusionsDuring the early period of ECMO support, the coagulation profiles and lactate levels exhibited different trajectories in survivors and non-survivors. Furthermore, the pre-ECMO DIC score plus lactate level was the best predictor of hospital death.
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