ArticleOncotarget2018
Clinical implication of a quantitative frailty assessment tool for prognosis in patients with urological cancers.
Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Multicenter prospective study validating the efficacy of a quantitative assessment tool for frailty in patients with urological cancers.Medical oncology (Northwood, London, England) · 2019Trial
- Exploring Patient Perspectives on Upper Tract Urothelial Cancer: A Qualitative Interview Study.Oncology and therapy · 2026Article
- Review
- Utility of the Age Discrepancy between Frailty-Based Biological Age and Expected Life Age in Patients with Urological Cancers.Cancers · 2022Article
- Relationship of frailty with treatment modality selection in patients with muscle-invasive bladder cancer (FRART-BC study).Translational andrology and urology · 2021Article
- Evaluation of comorbidity indices in determining the most suitable candidates for uro-oncological surgeries in elderly men.Central European journal of urology · 2021Article
- Frailty is a predictor of moderate to severe pain after robot-assisted laparoscopic prostatectomy: A case-control study (FRAP study).BJUI compass · 2020Article
- Postoperative weight loss followed by radical cystectomy predicts poor prognosis in patients with muscle-invasive bladder cancer.Medical oncology (Northwood, London, England) · 2018Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOptimal tools for evaluating frailty among urological cancer patients remain unclear. We aimed to develop a quantitative frailty assessment tool comparing healthy individuals and urological cancer patients, and investigate the clinical implication of quantitative frailty on prognosis in urological cancer patients.
resultsGait speed, hemoglobin, serum albumin, exhaustion, and depression were significantly worse in patients with all types of cancers than in pair-matched controls. Frailty discriminant score (FDS) showed clear separation between controls and urological cancer patients, and significant association with the Fried criteria. Overall survivals were significantly shorter in patients with a higher score (>2.30) than in those with a lower score among nonprostate cancer (bladder, upper tract urothelial carcinoma, and renal cell carcinoma) patients. In prostate cancer patients, overall survivals were significantly shorter in patients with a higher score (>3.30) than in those with a lower score.
conclusionsFDS was significantly associated with frailty and prognosis in urological cancer patients. This tool for frailty assessment can help patients and physicians make more informed decisions. Further validation study is needed. MATERIALS AND
methodsTotal 605 urological cancer patients presenting to our hospital underwent a prospective frailty assessment. Controls were selected from 2280 community-dwelling subjects. Frailty was assessed via physical status, blood biochemical tests, and mental status. We compared frailty variables between pair-matched controls and urological cancer patients. We developed FDS using frailty variables, and compared with the Fried criteria. The influence of FDS on overall survivals was investigated by Kaplan-Meier analysis and Cox regression analysis.
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