Evidence map›Paper›PMID 29706903›Full record

ArticleFrontiers in physiology2018

High Molecular Weight Polymer Promotes Bone Health and Prevents Bone Loss Under

Sandi Raehtz, Billy M Hargis, Vivek A Kuttappan, Rifat Pamukcu, Lisa R Bielke, Laura R McCabe

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. JBMR plus · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Immune Response toFrontiers in immunology · 2020
    Article
  17. Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sandi RaehtzDepartment of Physiology, Michigan State University, East Lansing, MI, United States.
Billy M HargisDepartment of Poultry Science, University of Arkansas, Fayetteville, AR, United States.
Vivek A KuttappanDepartment of Poultry Science, University of Arkansas, Fayetteville, AR, United States.
Rifat PamukcuMidway Pharmaceuticals, Spring House, PA, United States.
Lisa R BielkeDepartment of Animal Science, Ohio State University, Columbus, OH, United States.
Laura R McCabeDepartment of Physiology, Michigan State University, East Lansing, MI, United States.
Michigan State University · USUniversity of Arkansas at Fayetteville · USMidway College · USThe Ohio State University · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Mechanistic basis of probiotic prevention of osteoporosisR01AT007695 · NCCIH · MICHIGAN STATE UNIVERSITY · PI BRITTON, ROBERT A, MCCABE, LAURA R · 2013 to 2017
$2.2M
The Role of the Gut and Bone Microenvironment in T1D Bone LossR01DK101050 · NIDDK · MICHIGAN STATE UNIVERSITY · PI MCCABE, LAURA R, PARAMESWARAN, NARAYANAN · 2014 to 2016
$1.1M
NCCIH NIH HHS R01 AT007695NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK101050
6 · The paper itself

Abstract

As a consequence of rapid growth, broiler chickens are more susceptible to infection as well as bone fractures that result in birds being culled. Intestinal infection/inflammation has been demonstrated to promote bone loss in mice and humans. Given this link, we hypothesize that therapeutics that target the gut can benefit bone health. To test this, we infected broiler chickens (7 days old) with

Indexed as

bonefemoral-neckgutintestinemicrobiomeosteoporosispoultrySalmonella

Identifiers

PMID29706903
PMCPMC5908899
OpenAlexW2797754862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.