ArticleMetabolomics : Official journal of the Metabolomic Society2017
An untargeted metabolomics method for archived newborn dried blood spots in epidemiologic studies.
Article in Metabolomics : Official journal of the Metabolomic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 75 citations in OpenAlex.
- Newborn metabolomics linking prenatal air pollution exposure and autism spectrum disorder risk in children.Journal of exposure science & environmental epidemiology · 2026Article
- Evaluating 1,4-Dioxane Exposure in Long Island, New York: Integrating Environmental, Biological, and Metabolomic Measures.Environmental science & technology · 2026Article
- Nontargeted screening identifies mixtures of environmental pollutants that are associated with perturbations to amino acid and fatty acid metabolic pathways during early pregnancy.Environment international · 2026Article
- The Unique Utility of Newborn Dried Blood Spots for Driving Discovery in Childhood Cancer Research.Clinical chemistry · 2025Review
- Per- and polyfluoroalkyl substance concentrations during pregnancy and at birth and risk of childhood acute lymphoblastic leukemia.Environmental research · 2025Article
- Molecular Reactivity in Maternal Pregnancy Blood and Neonatal Dried Blood Spots Is Associated with the Risk of Pediatric Acute Lymphoblastic Leukemia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Prenatal Nitrogen Oxide (NOEnvironmental science & technology · 2025Article
- Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment.Nature communications · 2025Article
- Longitudinal urine metabolic profiling and gestational age prediction in human pregnancy.Briefings in bioinformatics · 2024Article
- Comparison of maternal venous blood metabolomics collected as dried blood spots, dried blood microsamplers, and plasma for integrative environmental health research.Environment international · 2024Article
- Effects of storage temperature and time on metabolite profiles measured in dried blood spots, dried blood microsamplers, and plasma.The Science of the total environment · 2024Article
- Metabolomic Effects of Folic Acid Supplementation in Adults: Evidence from the FACT Trial.The Journal of nutrition · 2024Article
- [Application of multiomics mass spectrometry in the research of chemical exposome].Se pu = Chinese journal of chromatography · 2024Review
- Metabolite Stability in Archived Neonatal Dried Blood Spots Used for Epidemiologic Research.American journal of epidemiology · 2023Article
- Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.Journal of exposure science & environmental epidemiology · 2023Article
- A global metabolomics minefield: Confounding effects of preanalytical factors when studying rare disorders.Analytical science advances · 2023Article
- Review
- Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation.Nature communications · 2023Article
- Article
- Advancing Exposomic Research in Prenatal Respiratory Disease Programming.Immunology and allergy clinics of North America · 2023Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
introductionFor pediatric diseases like childhood leukemia, a short latency period points to in-utero exposures as potentially important risk factors. Untargeted metabolomics of small molecules in archived newborn dried blood spots (DBS) offers an avenue for discovering early-life exposures that contribute to disease risks.
objectivesThe purpose of this study was to develop a quantitative method for untargeted analysis of archived newborn DBS for use in an epidemiological study (California Childhood Leukemia Study, CCLS).
methodsUsing experimental DBS from the blood of an adult volunteer, we optimized extraction of small molecules and integrated measurement of potassium as a proxy for blood hematocrit. We then applied this extraction method to 4.7-mm punches from 106 control DBS samples from the CCLS. Sample extracts were analyzed with liquid chromatography high resolution mass spectrometry (LC-HRMS) and an untargeted workflow was used to screen for metabolites that discriminate population characteristics such as sex, ethnicity, and birth weight.
resultsThousands of small molecules were measured in extracts of archived DBS. Normalizing for potassium levels removed variability related to varying hematocrit across DBS punches. Of the roughly 1,000 prevalent small molecules that were tested, multivariate linear regression detected significant associations with ethnicity (3 metabolites) and birth weight (15 metabolites) after adjusting for multiple testing.
conclusionsThis untargeted workflow can be used for analysis of small molecules in archived DBS to discover novel biomarkers, to provide insights into the initiation and progression of diseases, and to provide guidance for disease prevention.
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