ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018
Frontostriatal Dysfunction During Decision Making in Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Cognitive Correlates of Risky Decision-Making in Individuals with and without ADHD: A Meta-analysis.Neuropsychology review · 2025Pooled it
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Abnormalities of Localized Connectivity in Obsessive-Compulsive Disorder: A Voxel-Wise Meta-Analysis.Frontiers in human neuroscience · 2021Pooled it
- Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.Biological psychiatry · 2019Pooled it
- A randomized clinical trial of repeated doses of psilocybin for the treatment of obsessive-compulsive disorder.Journal of psychopharmacology (Oxford, England) · 2026Trial
- The effects of increasing and decreasing dopamine on inhibition of return: a psychopharmacological investigation.Experimental brain research · 2026Article
- Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neuromodulation and neural networks in psychiatric disorders: current status and emerging prospects.Psychological medicine · 2025Review
- Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study.Translational psychiatry · 2025Article
- Metaanalysis of Repetitive Transcranial Magnetic Stimulation (rTMS) Efficacy for OCD Treatment: The Impact of Stimulation Parameters, Symptom Subtype and rTMS-Induced Electrical Field.Journal of clinical medicine · 2024Review
- Compulsive avoidance in youths and adults with OCD: an aversive pavlovian-to-instrumental transfer study.Translational psychiatry · 2024Article
- Atypical neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD).European child & adolescent psychiatry · 2024Article
- Latent profiles of substance use, early life stress, and attention/externalizing problems and their association with neural correlates of reinforcement learning in adolescents.Psychological medicine · 2023Article
- Disorder-specific cingulo-opercular network hyperconnectivity in pediatric OCD relative to pediatric anxiety.Psychological medicine · 2023Article
- Altered brain functional network topology in Obsessive-Compulsive Disorder: A comparison of patients with varying severity of depressive symptoms and the impact on psychosocial functioning.NeuroImage. Clinical · 2023Article
- Atypical action updating in a dynamic environment associated with adolescent obsessive-compulsive disorder.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- The orbitofrontal cortex represents advantageous choice in the Iowa gambling task.Human brain mapping · 2022Article
- Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects.Frontiers in psychiatry · 2022Article
- Association of Environmental Uncertainty With Altered Decision-making and Learning Mechanisms in Youths With Obsessive-Compulsive Disorder.JAMA network open · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe aim of the current paper is to provide the first comparison of computational mechanisms and neurofunctional substrates in adolescents with attention-deficit/hyperactivity disorder (ADHD) and adolescents with obsessive-compulsive disorder (OCD) during decision making under ambiguity.
methodsSixteen boys with ADHD, 20 boys with OCD, and 20 matched control subjects (12-18 years of age) completed a functional magnetic resonance imaging version of the Iowa Gambling Task. Brain activation was compared between groups using three-way analysis of covariance. Hierarchical Bayesian analysis was used to compare computational modeling parameters between groups.
resultsPatient groups shared reduced choice consistency and relied less on reinforcement learning during decision making relative to control subjects, while adolescents with ADHD alone demonstrated increased reward sensitivity. During advantageous choices, both disorders shared underactivation in ventral striatum, while OCD patients showed disorder-specific underactivation in the ventromedial orbitofrontal cortex. During outcome evaluation, shared underactivation to losses in patients relative to control subjects was found in the medial prefrontal cortex and shared underactivation to wins was found in the left putamen/caudate. ADHD boys showed disorder-specific dysfunction in the right putamen/caudate, which was activated more to losses in patients with ADHD but more to wins in control subjects.
conclusionsThe findings suggest shared deficits in using learned reward expectancies to guide decision making, as well as shared dysfunction in medio-fronto-striato-limbic brain regions. However, findings of unique dysfunction in the ventromedial orbitofrontal cortex in OCD and in the right putamen in ADHD indicate additional, disorder-specific abnormalities and extend similar findings from inhibitory control tasks in the disorders to the domain of decision making under ambiguity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.