Evidence map›Paper›PMID 29706431›Full record

ArticleInternational journal of cardiology2018

Atrial remodeling and metabolic dysfunction in idiopathic isolated fibrotic atrial cardiomyopathy.

Chang Cui, Xiaohong Jiang, Weizhu Ju, Jiaxian Wang, Daowu Wang, Zheng Sun, Minglong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chang CuiDivision of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xiaohong JiangDivision of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Weizhu JuDivision of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jiaxian WangDivision of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; National Center for Human Genetics, National Research Institute for Family Planning, Beijing 100081, China.
Daowu WangState Key Laboratory in Reproductive Medicine, Centre for Clinical Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Zheng SunDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77054, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77054, USA.
Minglong ChenDivision of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: chenminglong@njmu.edu.cn.
Jiangsu Province Hospital · CNBaylor College of Medicine · USNanjing Medical University · CN

Funding

Gender-Specific Effects of Arsenic in DiabetesR01ES027544 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2021
$2.2M
Epigenomic Remodeling of Metabolism by Exercise through AP-1R01DK111436 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2020
$2.0M
De facto Target of Histone Deacetylase InhibitorsR21CA215591 · NCI · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2018
$345k
NCI NIH HHS R21 CA215591NIDDK NIH HHS R01 DK111436NIEHS NIH HHS R01 ES027544
6 · The paper itself

Abstract

backgroundIdiopathic isolated fibrotic atrial cardiomyopathy (IIF-ACM) is a novel subtype of cardiomyopathy characterized by atrial fibrosis that does not involve the ventricular myocardium and is associated with significant atrial tachyarrhythmia. The mechanisms underlying its pathogenesis are unknown.

methodsAtrium samples were obtained from 3 patients with IIF-ACM via surgical intervention. Control samples were consisted of 3 atrium biopsies from patients with congenital heart disease and normal sinus rhythm, matched for gender, age and basic clinical characteristics. Comparative histology, immunofluorescence staining, electron microscopy and proteomics analyses were carried out to explore the unique pathogenesis of IIF-ACM.

resultsIIF-ACM atria displayed disordered myofibrils, profound fibrosis and mitochondrial damages compared to the control atria. Proteomics profiling identified metabolic pathways as the most profound changes in IIF-ACM.

conclusionsOur study suggested that metabolic changes in the atrial myocardium caused mitochondrial oxidative stress and potential cell damage, which further led to atrial fibrosis and myofibril disorganization, the characteristic phenotype of IIF-ACM.

Indexed as

Atrial RemodelingCardiomyopathiesFemaleFibrosisHeart AtriaHumansMaleMetabolic DiseasesOxidative StressProteomicsFibrosisHistologyIIF-ACMMetabolismOxidative stressProteomics

Identifiers

PMID29706431
PMCPMC6188944
OpenAlexW2802391152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.