ArticleAmerican journal of human genetics2018
Whole-Exome Sequencing Reveals Uncaptured Variation and Distinct Ancestry in the Southern African Population of Botswana.
Article in American journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- High KIR diversity in Uganda and Botswana children living with HIV.Human immunology · 2026Article
- BeyondFrontiers in genetics · 2026Review
- High resolution class I HLA-A, -B, and -C diversity in Eastern and Southern African populations.Scientific reports · 2025Article
- Identification of a Clade-Specific HLA-C*03:02 CTL Epitope GY9 Derived from the HIV-1 p17 Matrix Protein.International journal of molecular sciences · 2024Article
- Precision ophthalmology: a call for Africa not to be left in the dark.Gene therapy · 2024Article
- Physical activity alters the effect of genetic determinants of adiposity on hypertension among individuals of European ancestry in the UKB.Scandinavian journal of medicine & science in sports · 2024Article
- Antiracist Documentation Practices - Shaping Clinical Encounters and Decision Making.The New England journal of medicine · 2023Article
- The future of sickle cell disease therapeutics rests in genomics.Disease models & mechanisms · 2023Article
- Determinants of participation in glaucoma genomic research in South East Nigeria: A cross-sectional analytical study.PloS one · 2023Article
- Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes.Frontiers in genetics · 2023Article
- MPYS Modulates Fatty Acid Metabolism and Immune Tolerance at Homeostasis Independent of Type I IFNs.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- A functional genomics approach in Tanzanian population identifies distinct genetic regulators of cytokine production compared to European population.American journal of human genetics · 2022Article
- Advances in integrative African genomics.Trends in genetics : TIG · 2022Review
- Simulation of African and non-African low and high coverage whole genome sequence data to assess variant calling approaches.Briefings in bioinformatics · 2021Article
- African genetic diversity and adaptation inform a precision medicine agenda.Nature reviews. Genetics · 2021Review
- Bantu-speaker migration and admixture in southern Africa.Human molecular genetics · 2021Review
- Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression.NPJ genomic medicine · 2021Article
- Functional Characterisation of Three GlycineInternational journal of molecular sciences · 2021Article
- Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection.Scientific reports · 2021Article
- Exome Sequencing Reveals a Putative Role for HLA-C*03:02 in Control of HIV-1 in African Pediatric Populations.Frontiers in genetics · 2021Article
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30 authors.
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Abstract
Large-scale, population-based genomic studies have provided a context for modern medical genetics. Among such studies, however, African populations have remained relatively underrepresented. The breadth of genetic diversity across the African continent argues for an exploration of local genomic context to facilitate burgeoning disease mapping studies in Africa. We sought to characterize genetic variation and to assess population substructure within a cohort of HIV-positive children from Botswana-a Southern African country that is regionally underrepresented in genomic databases. Using whole-exome sequencing data from 164 Batswana and comparisons with 150 similarly sequenced HIV-positive Ugandan children, we found that 13%-25% of variation observed among Batswana was not captured by public databases. Uncaptured variants were significantly enriched (p = 2.2 × 10
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