ArticleJournal of the American Academy of Child and Adolescent Psychiatry2018
Irritability Trajectories, Cortical Thickness, and Clinical Outcomes in a Sample Enriched for Preschool Depression.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Systematic Review and Meta-Analysis: Early Irritability as a Transdiagnostic Neurodevelopmental Vulnerability to Later Mental Health Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Pooled it
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Application of a diathesis-stress model to the interplay of cortical structural development and emerging depression in youth.Clinical psychology review · 2020Pooled it
- Foster Care Leads to Lower Irritability Among Adolescents with a History of Early Psychosocial Deprivation.Research on child and adolescent psychopathology · 2024Trial
- Joint Developmental Trajectories of Irritability and Executive Function: Associations with Time-varying Psychopathological Problems among Chinese Adolescents.Research on child and adolescent psychopathology · 2026Article
- Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Inhibition-related connectivity predicts irritability risk and resilience across early adolescence.Social cognitive and affective neuroscience · 2026Article
- Article
- Genetic and Environmental Influences on the Development of Irritability from Ages 3 to 5 Years.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2025Article
- Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Irritability in Youths: A Critical Integrative Review.The American journal of psychiatry · 2024Review
- Irritability, Negative Life Events and the Course of Anxiety and Depressive Symptoms in a Clinical Sample of Youth: A Longitudinal Study.JAACAP open · 2024Article
- Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications.International journal of methods in psychiatric research · 2023Article
- Offspring irritability: associations with parental psychopathology and personality.European child & adolescent psychiatry · 2023Article
- A stable and replicable neural signature of lifespan adversity in the adult brain.Nature neuroscience · 2023Article
- Roads Diverged: Developmental Trajectories of Irritability From Toddlerhood Through Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Cross-sectional and Longitudinal Associations of Anxiety and Irritability With Adolescents' Neural Responses to Cognitive Conflict.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveCross-sectional, longitudinal, and genetic associations exist between irritability and depression. Prior studies have examined developmental trajectories of irritability, clinical outcomes, and associations with child and familial depression. However, studies have not integrated neurobiological measures. The present study examined developmental trajectories of irritability, clinical outcomes, and cortical structure among preschoolers oversampled for depressive symptoms.
methodBeginning at 3 to 5 years old, a sample of 271 children enriched for early depressive symptoms were assessed longitudinally by clinical interview. Latent class mixture models identified trajectories of irritability severity. Risk factors, clinical outcomes, and cortical thickness were compared across trajectory classes. Cortical thickness measures were extracted from 3 waves of magnetic resonance imaging at 7 to 12 years of age.
resultsThree trajectory classes were identified among these youth: 53.50% of children exhibited elevated irritability during preschool that decreased longitudinally, 30.26% exhibited consistently low irritability, and 16.24% exhibited consistently elevated irritability. Compared with other classes, the elevated irritability class exhibited higher rates of maternal depression, early life adversity, later psychiatric diagnoses, and functional impairment. Further, elevated baseline irritability predicted later depression beyond adversity and personal and maternal depression history. The elevated irritability class exhibited a thicker cortex in the left superior frontal and temporal gyri and the right inferior parietal lobule.
conclusionIrritability manifested with specific developmental trajectories in this sample enriched for early depression. Persistently elevated irritability predicted poor psychiatric outcomes, higher risk for later depression, and decreased overall function later in development. Greater frontal, temporal, and parietal cortical thickness also was found, providing neural correlates of this risk trajectory.
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