ArticleBMC biology2018
Position-specific intron retention is mediated by the histone methyltransferase SDG725.
Article in BMC biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 41 citations in OpenAlex.
- H3K36 methyltransferase SDG102 enhances salt tolerance by altering the methylation level of genes in maize (Zea mays L.).BMC plant biology · 2026Article
- Functional Analysis of MaizePlants (Basel, Switzerland) · 2025Article
- Intron Retention: A Reemerging Paradigm in RNA Biology and Post-Transcriptional Gene Regulation.Genes · 2025Review
- H3K36 methylation stamps transcription resistive to preserve development in plants.Nature plants · 2025Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2024Article
- Genome-wide identification and expression analysis of the SET domain-containing gene family in potato (Solanum tuberosum L.).BMC genomics · 2024Article
- Transcriptome analysis reveals the effect of cold storage time on the expression of genes related to oxidative metabolism in Chinese black truffle.Frontiers in nutrition · 2024Article
- Transcriptomics reveals a core transcriptional network of K-type cytoplasmic male sterility microspore abortion in wheat (Triticum aestivum L.).BMC plant biology · 2023Article
- Alternative Splicing Variation: Accessing and Exploiting in Crop Improvement Programs.International journal of molecular sciences · 2023Review
- Plant Intron-Splicing Efficiency Database (PISE): exploring splicing of ∼1,650,000 introns in Arabidopsis, maize, rice, and soybean from ∼57,000 public RNA-seq libraries.Science China. Life sciences · 2023Article
- Increased chromatin accessibility facilitates intron retention in specific cell differentiation states.Nucleic acids research · 2022Article
- Rapid Regulation of Alternative Splicing in Response to Environmental Stresses.Frontiers in plant science · 2022Review
- A dynamic intron retention program regulates the expression of several hundred genes during pollen meiosis.Plant reproduction · 2021Article
- Ectopic Overexpression of Histone H3K4 Methyltransferase CsSDG36 from Tea Plant Decreases Hyperosmotic Stress Tolerance inInternational journal of molecular sciences · 2021Article
- Chromatin regulation in plant hormone and plant stress responses.Current opinion in plant biology · 2020Review
- Distinct Evolutionary Origins of Intron Retention Splicing Events inFrontiers in plant science · 2020Article
- The changing paradigm of intron retention: regulation, ramifications and recipes.Nucleic acids research · 2019Review
- Highly ABA-Induced 1 (HAI1)-Interacting protein HIN1 and drought acclimation-enhanced splicing efficiency at intron retention sites.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment.Nature communications · 2019Article
- H3K4me2 functions as a repressive epigenetic mark in plants.Epigenetics & chromatin · 2019Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntron retention (IR), the most prevalent alternative splicing form in plants, plays a critical role in gene expression during plant development and stress response. However, the molecular mechanisms underlying IR regulation remain largely unknown.
resultsKnockdown of SDG725, a histone H3 lysine 36 (H3K36)-specific methyltransferase in rice, leads to alterations of IR in more than 4700 genes. Surprisingly, IR events are globally increased at the 5' region but decreased at the 3' region of the gene body in the SDG725-knockdown mutant. Chromatin immunoprecipitation sequencing analyses reveal that SDG725 depletion results in a genome-wide increase of the H3K36 mono-methylation (H3K36me1) but, unexpectedly, promoter-proximal shifts of H3K36 di- and tri-methylation (H3K36me2 and H3K36me3). Consistent with the results in animals, the levels of H3K36me1/me2/me3 in rice positively correlate with gene expression levels, whereas shifts of H3K36me2/me3 coincide with position-specific alterations of IR. We find that either H3K36me2 or H3K36me3 alone contributes to the positional change of IR caused by SDG725 knockdown, although IR shift is more significant when both H3K36me2 and H3K36me3 modifications are simultaneously shifted.
conclusionsOur results revealed that SDG725 modulates IR in a position-specific manner, indicating that H3K36 methylation plays a role in RNA splicing, probably by marking the retained introns in plants.
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