ArticleBMC medicine2018
When complexity science meets implementation science: a theoretical and empirical analysis of systems change.
Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 354 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
354 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Pooled it
- A transdisciplinary framework for chronic illness and chronic pain: a sequential qualitative meta-synthesis.Frontiers in public health · 2026Pooled it
- Exploring the link between healthcare organizational culture and provider work satisfaction: a systematic review.BMC health services research · 2025Pooled it
- Investigating the implementation of infection prevention and control practices in neonatal care across country income levels: a systematic review.Antimicrobial resistance and infection control · 2025Pooled it
- What is known about near miss events in the operating room? A systematic review of studies of mixed methods design.Irish journal of medical science · 2025Pooled it
- Systems approaches to scaling up: a systematic review and narrative synthesis of evidence for physical activity and other behavioural non-communicable disease risk factors.The international journal of behavioral nutrition and physical activity · 2024Pooled it
- Transitional Care Interventions From Hospital to Community to Reduce Health Care Use and Improve Patient Outcomes: A Systematic Review and Network Meta-Analysis.JAMA network open · 2023Pooled it
- Combining systems thinking approaches and implementation science constructs within community-based prevention: a systematic review.Health research policy and systems · 2023Pooled it
- Organisation and integrated healthcare approaches for people living with HIV, multimorbidity, or both: a systematic review.BMC public health · 2023Pooled it
- Identifying and understanding benefits associated with return-on-investment from large-scale healthcare Quality Improvement programmes: an integrative systematic literature review.BMC health services research · 2022Pooled it
- Process Evaluation of a Randomized Controlled Trial of an Enhanced Rehabilitation Transition Program for Stroke Survivors.Archives of physical medicine and rehabilitation · 2026Trial
- User journey method: a case study for improving digital intervention use measurement.BMC health services research · 2025Trial
- An integrated, multidisciplinary management team intervention to improve patient-centeredness, HIV, and maternal-child outcomes in Lesotho: formative research on participatory implementation strategies.BMC health services research · 2024Trial
- Implementation outcomes from a multi-site stepped wedge cluster randomized family caregiver skills training trial.Health services research · 2024Trial
- Factors influencing fidelity to guideline implementation strategies for improving pain care at cancer centres: a qualitative sub-study of the Stop Cancer PAIN Trial.BMC health services research · 2024Trial
- Factors facilitating the implementation of a clinical decision support system in primary care practices: a fuzzy set qualitative comparative analysis.BMC health services research · 2023Trial
- "It's all about the money": an interpretive description of embedding physical therapy-led falls prevention group exercise in long-term care.BMC geriatrics · 2023Trial
- Developmental Systems Cardiology III: Measuring Adaptation Across the Lifespan.Pediatric cardiology · 2026Article
- De-Escalation in United Kingdom Inpatient Mental Health Care: A Structured Critical Narrative Synthesis of People, Capability and Context.International journal of mental health nursing · 2026Review
- The Nursing Implementation Complexity Tool for Digital Technology Implementation in Nursing: Design Science Research Study.Journal of medical Internet research · 2026Article
294 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundImplementation science has a core aim - to get evidence into practice. Early in the evidence-based medicine movement, this task was construed in linear terms, wherein the knowledge pipeline moved from evidence created in the laboratory through to clinical trials and, finally, via new tests, drugs, equipment, or procedures, into clinical practice. We now know that this straight-line thinking was naïve at best, and little more than an idealization, with multiple fractures appearing in the pipeline. DISCUSSION: The knowledge pipeline derives from a mechanistic and linear approach to science, which, while delivering huge advances in medicine over the last two centuries, is limited in its application to complex social systems such as healthcare. Instead, complexity science, a theoretical approach to understanding interconnections among agents and how they give rise to emergent, dynamic, systems-level behaviors, represents an increasingly useful conceptual framework for change. Herein, we discuss what implementation science can learn from complexity science, and tease out some of the properties of healthcare systems that enable or constrain the goals we have for better, more effective, more evidence-based care. Two Australian examples, one largely top-down, predicated on applying new standards across the country, and the other largely bottom-up, adopting medical emergency teams in over 200 hospitals, provide empirical support for a complexity-informed approach to implementation. The key lessons are that change can be stimulated in many ways, but a triggering mechanism is needed, such as legislation or widespread stakeholder agreement; that feedback loops are crucial to continue change momentum; that extended sweeps of time are involved, typically much longer than believed at the outset; and that taking a systems-informed, complexity approach, having regard for existing networks and socio-technical characteristics, is beneficial.
conclusionConstruing healthcare as a complex adaptive system implies that getting evidence into routine practice through a step-by-step model is not feasible. Complexity science forces us to consider the dynamic properties of systems and the varying characteristics that are deeply enmeshed in social practices, whilst indicating that multiple forces, variables, and influences must be factored into any change process, and that unpredictability and uncertainty are normal properties of multi-part, intricate systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.