Evidence map›Paper›PMID 29705971›Full record

ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2018

Roles of catechol neurochemistry in autonomic function testing.

David S Goldstein, William P Cheshire

Open access · greenAbstract readReview
In one paragraph

Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Long-term outcomes of hyperadrenergic orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Article
  4. Article
  5. Peripheral catecholamine systems: an evolutionary perspective.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Review
  6. 3,4-Dihydroxyphenylglycol levels separate multiple system atrophy from Parkinson disease with orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Observational
  7. Engineering non-P450 3-hydroxylase forSynthetic and systems biotechnology · 2025
    Article
  8. "Body-first" dementia with Lewy bodies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  9. Peripheral autonomic failure is associated with more severe postprandial hypotension compared to central autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Baroreflex-sympathoneural dysfunction characterizes at-risk individuals with preclinical central Lewy body diseases.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Article
  16. Observational
  17. Role of adrenergic receptors in shock.Frontiers in physiology · 2023
    Review
  18. Mussel-inspired biomaterials: From chemistry to clinic.Bioengineering & translational medicine · 2022
    Review
  19. Review
  20. Dysautonomia: A Forgotten Condition - Part II.Arquivos brasileiros de cardiologia · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David S GoldsteinClinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike MSC-1620, Building 10 Room 8N260, Bethesda, MD, 20892-1620, USA. goldsteind@ninds.nih.gov.ORCID 0000-0002-5709-9940
William P CheshireDepartment of Neurology, Mayo Clinic, Jacksonville, FL, 32224, USA.
Mayo Clinic in Florida · USNational Institutes of Health · US

Funding

Biomarkers of Parkinson Disease and Related DisordersZIANS003034 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2009 to 2025
$22.8M
Biomarkers of Parkinson Disease and Related DisordersZ01NS003034 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2007 to 2008
$3.9M
Mechanisms of Parkinson Disease and Related DisordersZ01NS003033 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2007 to 2008
$966k
Neurocardiology: Catecholamine Systems In Stress and DisZ01NS002979 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID S · 1999 to 2006
–
Intramural NIH HHS Z01 NS002979Intramural NIH HHS Z01 NS003033Intramural NIH HHS Z01 NS003034Intramural NIH HHS Z99 NS999999NINDS NIH HHS 1ZIANS003034
6 · The paper itself

Abstract

Catechols are a class of compounds that contain adjacent hydroxyl groups on a benzene ring. Endogenous catechols in human plasma include the catecholamines norepinephrine, epinephrine (adrenaline), and dopamine; the catecholamine precursor DOPA, 3,4-dihydroxyphenylglycol (DHPG), which is the main neuronal metabolite of norepinephrine; and 3,4-dihydroxyphenylacetic acid (DOPAC), which is the main neuronal metabolite of dopamine. In the diagnostic evaluation of patients with known or suspected dysautonomias, measurement of plasma catechols is rarely diagnostic but often is informative. This review summarizes the roles of clinical catechol neurochemistry in autonomic function testing.

Indexed as

AnimalsAutonomic Nervous SystemAutonomic Nervous System DiseasesCatecholaminesCatecholsHumansNeurochemistryCatecholaminesCatecholsAutonomicCatecholDHPGNorepinephrineSympathetic

Identifiers

PMID29705971
PMCPMC8895275
OpenAlexW2802939829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.