SynthesisNeuropsychology review2018
The Study of Language in the Amyotrophic Lateral Sclerosis - Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives.
Synthesis in Neuropsychology review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Early cognitive decline in amyotrophic lateral sclerosis and its relation to driving: an observational study.Journal of rehabilitation medicine · 2025Observational
- Association between cardiac autonomic dysfunction, cognitive impairment, and survival in patients with amyotrophic lateral sclerosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Ecological validity of performance-based cognitive screeners in amyotrophic lateral sclerosis: preliminary evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Assessment of Language Function in Older Mandarin-Speaking Adults with Mild Cognitive Impairment using Multifaceted Language Tests.Journal of Alzheimer's disease : JAD · 2024Article
- The involvement of language-associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional alterations.Brain and behavior · 2023Article
- Prevalence and determinants of language impairment in non-demented amyotrophic lateral sclerosis patients.European journal of neurology · 2023Article
- Bulbar involvement and cognitive features in amyotrophic lateral sclerosis: a retrospective study on 347 patients.Frontiers in aging neuroscience · 2023Article
- Cognitive and neuropsychiatric endophenotypes in amyotrophic lateral sclerosis.Brain communications · 2023Article
- Cognitive and behavioral involvement in ALS has been known for more than a century.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Identifying key signs of motor neurone disease in primary care: a nested case-control study using the QResearch database.BMJ open · 2022Article
- Patterns of Language Impairment in Early Amyotrophic Lateral Sclerosis.Neurology. Clinical practice · 2021Article
- Pathophysiology and Treatment of Non-motor Dysfunction in Amyotrophic Lateral Sclerosis.CNS drugs · 2021Review
- Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies.Frontiers in neurology · 2021Review
- Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder.Scientific reports · 2020Article
- Speech network regional involvement in bulbar ALS: a multimodal structural MRI study.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2019Article
- Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2019Article
- Unimpaired Neuropsychological Performance and Enhanced Memory Recall in Patients with Sbma: A Large Sample Comparative Study.Scientific reports · 2018Article
- Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Amyotrophic Lateral Sclerosis is a neurodegenerative disorder characterized primarily by motor network disruption. Extra-motor manifestations including executive functions, social cognition, and behavioral changes are now well recognized as important features of ALS, and are associated with frontotemporal and frontostriatal network disruption. However, the presence and characterization of language changes has received less attention. This systematic review characterizes the profile of reported language dysfunction in ALS. PRISMA guidelines were implemented to carry out and report the review. Current evidence suggests that areas of neuroanatomical disruption in ALS spread to language centers such as posterior, inferior frontal and superior temporal areas leading to deficits in word retrieval, syntactic and grammatical processing, and spelling. However, the majority of studies of language in ALS have been limited by the recruitment of small clinic-based prevalent samples and important questions remain regarding the incidence and progression of language impairment in ALS. Further studies from population-based incident cohorts will help to determine the range of language deficits in ALS, and how these relate to previously defined executive and behavioral sub-phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.