Evidence map›Paper›PMID 29705892›Full record

ArticleInternational ophthalmology2019

The ophthalmic diagnosis and management of four siblings with Werner syndrome.

C Lyons, D Gallagher, T McSwiney, E McElnea, F Kinsella

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In one paragraph

Article in International ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Ocular Manifestations in Patients with Werner Syndrome.International journal of molecular sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

C LyonsDepartment of Ophthalmology, University Hospital Galway, University Road, Galway, Ireland. clyons87@gmail.com.
D GallagherDepartment of Ophthalmology, University Hospital Galway, University Road, Galway, Ireland.
T McSwineyDepartment of Ophthalmology, University Hospital Galway, University Road, Galway, Ireland.
E McElneaDepartment of Ophthalmology, University Hospital Galway, University Road, Galway, Ireland.
F KinsellaDepartment of Ophthalmology, University Hospital Galway, University Road, Galway, Ireland.
University Hospital Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWerner syndrome is a rare autosomal recessive disorder caused by mutations in the Werner syndrome WRN gene, on chromosome 8. Those affected manifest early the features of ageing. DISCUSSION: Cataract surgery is prone to post-operative complications in those with Werner syndrome. The development of cystoid macular oedema (CMO) is likely multifactorial. Patients with WS have diabetes mellitus type 2 which can contribute to macular oedema. There is a deposition of abnormal WRN proteins in the macula which also predisposes to macular oedema. The trauma of cataract surgery appears to be the main stimulus for the development of CMO. CMO may, as a result, be difficult to manage in Werner syndrome patients.

conclusionFurther study is needed to elucidate the precise role of retinal WRN protein expression in the development of CMO in those with Werner syndrome. A tailored and more successful approach to the treatment of CMO in such patients may result.

Indexed as

Werner SyndromeAdultCataract ExtractionDiagnostic Techniques, OphthalmologicalFemaleHumansMacular EdemaMaleSiblingsTreatment OutcomeWerner Syndrome HelicaseWerner Syndrome HelicaseWRN protein, humanCataractCystoid macular oedemaWerner syndrome

Identifiers

PMID29705892
OpenAlexW2799644007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.