ArticleArchives of osteoporosis2018
Association between metabolic syndrome and osteoporosis in Taiwanese middle-aged and elderly participants.
Article in Archives of osteoporosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Prevalence of osteoporosis and incidence of related fractures in developed economies in the Asia Pacific region: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Pooled it
- Is diabetes mellitus a risk factor for low bone density: a systematic review and meta-analysis.BMC endocrine disorders · 2021Pooled it
- Fracture Risk Assessment in Metabolic Syndrome in Terms of Secondary Osteoporosis Potential. A Narrative Review.Calcified tissue international · 2025Review
- Contradictory links between lipid levels and bone health: atherogenic index of plasma and bone microarchitecture.Journal of orthopaedic surgery and research · 2025Article
- Metabolic syndrome in postmenopausal women with osteoporosis and its relationship with bone density and turnover markers.Reumatologia · 2025Article
- Associations of obesity defined comprehensively by body mass index and body fat percentage with osteopenia.Clinics (Sao Paulo, Brazil) · 2025Article
- Relative Contribution of Metabolic Syndrome Components in Relation to Obesity and Insulin Resistance in Postmenopausal Osteoporosis.Journal of clinical medicine · 2024Article
- A view on the skin-bone axis: unraveling similarities and potential of crosstalk.Frontiers in medicine · 2024Review
- Linking metabolic syndrome with low bone mass through insights from BMI and health behaviors.Scientific reports · 2023Article
- The Clinical Management of Deconditioned Patient.Archives of Razi Institute · 2022Article
- Association between metabolic syndrome and osteoporosis among adults aged 50 years and older: using the National Health Information Database in South Korea.Archives of osteoporosis · 2022Article
- Article
- Gender discrepancies in predictors for newly onset cardiovascular events and metabolic syndrome in elderly patients from rural China.Frontiers in cardiovascular medicine · 2022Article
- Obesity and Bone: A Complex Relationship.International journal of molecular sciences · 2021Review
- Associations between Metabolic Syndrome and Obesity-Related Indices and Bone Mineral Density T-Score in Hemodialysis Patients.Journal of personalized medicine · 2021Article
- Metabolic syndrome is associated to an increased risk of low bone mineral density in free-living women with suspected osteoporosis.Journal of endocrinological investigation · 2021Article
- Mood and Metabolic Health Status of Elderly Osteoporotic Patients in Korea: A Cross-Sectional Study of a Nationally Representative Sample.Healthcare (Basel, Switzerland) · 2021Article
- Association between Metabolic Syndrome and Osteoporosis: A Systematic Review and Meta-Analysis.International journal of endocrinology · 2021Review
- Association between metabolic syndrome and bone mineral density among menopausal Saudi women: Case-control study.Medical journal of the Islamic Republic of Iran · 2021Article
- Is the Occurrence or Reversal of Nonalcoholic Fatty Liver Disease Associated with Long-Term Helicobacter pylori Infection among Chinese Adults? A Cohort Study.Gastroenterology research and practice · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the association between metabolic syndrome and osteoporosis among middle-aged and elderly Taiwanese participants. After controlling for body mass index, age, liver and renal functions, and nutrition and exercise statuses, we found no significant association between MS and osteoporosis in either gender. PURPOSE: The term metabolic syndrome (MS) encompasses different abnormalities with independent effects on bone metabolism, which has led to inconsistencies in the association between MS and osteoporosis. This study evaluated this association among middle-aged and elderly Taiwanese participants by adjusting relevant covariates.
methodsWe enrolled 2007 participants (1045 men and 962 women) older than 50 years, who underwent a health examination at a preventive examination agency in urban Taiwan. We studied age, gender, diabetes mellitus and hypertension histories, smoking and exercise statuses, metabolic and nutrition indices, and liver and renal function profiles. We conducted multiple logistic regression analyses to examine the association between MS and osteoporosis by categorizing participants in terms of gender and body mass index (BMI).
resultsOverall, men with osteoporosis were less likely to have MS, and displayed fewer MS components than men without osteoporosis; but we found no significant associations between MS, or its components, and osteoporosis in women. After forming two groups according to BMI and adjusting for covariates, we found no association between MS and osteoporosis in any group. Multiple logistic regression analysis revealed that regular exercise had a negative association with osteoporosis in the low BMI group for men (OR, 0.365; p = 0.008).
conclusionsAfter BMI stratification and adjustments for age, nutrition status, liver and renal functions, and exercise status, we found no significant association between MS and osteoporosis in either gender. Regular exercise may prevent osteoporosis, particularly in men with a lean body mass.
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