ArticleDrug and alcohol dependence2018
Course of remission from and relapse to heavy drinking following outpatient treatment of alcohol use disorder.
Article in Drug and alcohol dependence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Applying methods for personalized medicine to the treatment of alcohol use disorder.Journal of consulting and clinical psychology · 2021Trial
- World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom.Addiction (Abingdon, England) · 2020Trial
- Maintenance of World Health Organization Risk Drinking Level Reductions and Posttreatment Functioning Following a Large Alcohol Use Disorder Clinical Trial.Alcoholism, clinical and experimental research · 2019Trial
- Predicting Outpatient Follow-Up Retention After Inpatient Treatment in Patients With Alcohol Use Disorder: A Data-Driven Random Forest Approach.Addiction biology · 2026Article
- Predictors and Trajectories of Negative and Positive Interpersonal Dynamics in Remission From Alcohol Use Disorder.Alcohol, clinical & experimental research · 2026Article
- Using digitally delivered measurement-based care in substance use disorder treatment: qualitative analysis of patients' perspectives.The American journal of drug and alcohol abuse · 2025Article
- Latent profiles of regulatory flexibility in alcohol use disorder: Associations with delay discounting and symptoms of depression, anxiety, and stress.Alcohol, clinical & experimental research · 2024Article
- Factors Associated with Relapses in Alcohol and Substance Use Disorder.The Eurasian journal of medicine · 2023Article
- Evaluation of 6 years of eHealth data in the alcohol use disorder field indicates improved efficacy of care.Frontiers in digital health · 2023Article
- Resting Hypoconnectivity of Theoretically Defined Addiction Networks during Early Abstinence Predicts Subsequent Relapse in Alcohol Use Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Two Filtering Methods of Forecasting Linear and Nonlinear Dynamics of Intensive Longitudinal Data.Psychometrika · 2022Article
- An operant ethanol self-administration paradigm that discriminates between appetitive and consummatory behaviors reveals distinct behavioral phenotypes in commonly used rat strains.Neuropharmacology · 2021Article
- Within-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes.Drug and alcohol dependence · 2021Article
- Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study.Scientific reports · 2021Article
- Compulsive alcohol consumption is regulated by dorsal striatum fast-spiking interneurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Patterns of transitions between relapse to and remission from heavy drinking over the first year after outpatient alcohol treatment and their relation to long-term outcomes.Journal of consulting and clinical psychology · 2020Article
- Reductions in Drinking Predict Increased Distress: Between- and Within-Person Associations between Alcohol Use and Psychological Distress During and Following Treatment.Alcoholism, clinical and experimental research · 2020Article
- Personalized Approach Bias Modification Smartphone App ("SWIPE") to Reduce Alcohol Use Among People Drinking at Hazardous or Harmful Levels: Protocol for an Open-Label Feasibility Study.JMIR research protocols · 2020Article
- Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.Alcoholism, clinical and experimental research · 2020Article
- The Role of Affect in Psychosocial Treatments for Substance Use Disorders.Current addiction reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe sought to understand alcohol behavior change as a process over time by identifying patterns of relapse and remission after outpatient treatment and evaluating how these patterns predict longer-term clinical outcomes.
methodWe conducted latent profile analyses using data from the outpatient arm in Project MATCH. Relapse and remission episodes were defined by the number of consecutive 14-day periods that included any heavy drinking days and no heavy drinking days. Indicators of each profile were: initial 2-week post-treatment remission/relapse status, number of remission/relapse transitions in the first year after treatment, duration of remission episodes, and duration of relapse episodes.
resultsWe identified 6 profiles: 1) "remission," 2) "transition to remission", 3) "few long transitions," 4) "many short transitions," 5) "transition to relapse," and 6) "relapse." Profile 1 had the best long-term outcomes. Long-term outcomes were not uniform among individuals with at least some heavy drinking (profiles 2 through 6; ∼75% of the sample). Individuals who transitioned back to and sustained periods of remission (profiles 2-4) had better long-term outcomes than those who failed to transition out of relapse (profiles 5-6) following treatment.
conclusionsPost-treatment change in alcohol use is a process in which individuals variably transition in and out of "relapse" and "remission" statuses. "Any heavy drinking" following treatment is not necessarily a sign of treatment failure. A more nuanced look at the process of AUD change by considering whether individuals are able to transition to and sustain periods of remission seems warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.