Evidence map›Paper›PMID 29705116›Full record

Trial reportThe Journal of pediatrics2018

Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial.

Colm P Travers, Waldemar A Carlo, Arie Nakhmani, Shweta Bhatia, Samuel J Gentle, VenkataNagaSai Apurupa Amperayani, Premananda Indic, Inmaculada Aban, Namasivayam Ambalavanan

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02794662 (Environmental or Nasal Cannula Oxygen for Preterm Infants Receiving Oxygen Therapy), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02794662 nacompletednot on this map

Environmental or Nasal Cannula Oxygen for Preterm Infants Receiving Oxygen Therapy: a Randomized Cross-over Pilot Study

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2016 to 2016Enrolled25ConditionsInfant, Newborn, Diseases, HypoxiaArmsOxygen Environment, Nasal Cannula Oxygen
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Colm P TraversDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. Electronic address: ctravers@peds.uab.edu.
Waldemar A CarloDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Arie NakhmaniDepartment of Electrical and Computer Engineering, University of Alabama at Birmingham, Birmingham, AL.
Shweta BhatiaUniversity of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC.
Samuel J GentleDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
VenkataNagaSai Apurupa AmperayaniDepartment of Electrical Engineering, University of Texas at Tyler, Tyler, TX.
Premananda IndicDepartment of Electrical Engineering, University of Texas at Tyler, Tyler, TX.
Inmaculada AbanDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL.
Namasivayam AmbalavananDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
University of Alabama at Birmingham · USThe University of Texas at Tyler · USUniversity of Alabama at Birmingham Hospital · USUniversity of North Carolina at Chapel Hill · US

Funding

UAB Health Services Research (HSR) Training ProgramT32HS013852 · AHRQ · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVITAN, EMILY B, MUGAVERO, MICHAEL J · 2003 to 2024
$8.0M
Pre-Vent ApneaU01HL133536 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM, INDIC, PREMANANDA PAI · 2016 to 2020
$2.6M
AHRQ HHS T32 HS013852NHLBI NIH HHS U01 HL133536
6 · The paper itself

Abstract

objectiveTo test the hypothesis that environmental compared with nasal cannula oxygen decreases episodes of intermittent hypoxemia (oxygen saturations <85% for ≥10 seconds) in preterm infants on supplemental oxygen by providing a more stable hypopharyngeal oxygen concentration. STUDY

designThis was a single center randomized crossover trial with a 1:1 parallel allocation to order of testing. Preterm infants on supplemental oxygen via oxygen environment maintained by a servo-controlled system or nasal cannula with flow rates ≤1.0 L per kg per minute were crossed over every 24 hours for 96 hours. Data were collected electronically to capture real time numeric and waveform data from patient monitors.

resultsTwenty-five infants with gestational age of 27 ± 2 weeks (mean ± SD) and a birth weight of 933 ± 328 g were studied at postnatal day 36 ± 26. The number of episodes of intermittent hypoxemia per 24 hours was 117 ± 77 (median, 98; range, 4-335) with oxygen environment vs 130 ± 63 (median, 136; range, 16-252) with nasal cannula (P = .002). Infants on oxygen environment compared with nasal cannula also had decreased episodes of severe intermittent hypoxemia (P = .005). Infants on oxygen environment compared with nasal cannula had a lower proportion of time with oxygen saturations <85% (.05 ± .03 vs .06 ± .03, P < .001), and a lower coefficient of variation of oxygen saturation (P = .02).

conclusionsIn preterm infants receiving supplemental oxygen, servo-controlled oxygen environment decreases hypoxemia compared with nasal cannula.

trial registrationClinicalTrials.gov: NCT02794662.

Indexed as

CannulaInfant, PrematureContinuous Positive Airway PressureCross-Over StudiesEquipment DesignFemaleGestational AgeHumansHypoxiaInfant, NewbornMaleNoseOxygen Inhalation Therapybronchopulmonary dysplasiaincubatorinfantintermittent hypoxemianeonatalneonatenewbornrespiratory distress syndromeservo-controlledsupplemental

Identifiers

PMID29705116
PMCPMC6109600
OpenAlexW2801006210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.