Evidence map›Paper›PMID 29704983›Full record

ArticleNeuropharmacology2018

Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys.

Ruifeng Liu, Jonathan Crawford, Patrick M Callahan, Alvin V Terry, Christos Constantinidis, David T Blake

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  6. Basal forebrain activation improves working memory in senescent monkeys.bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ruifeng LiuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China; Brain and Behavior Discovery Institute, Department of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Jonathan CrawfordBrain and Behavior Discovery Institute, Department of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Patrick M CallahanDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Alvin V TerryDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA.
Christos ConstantinidisDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
David T BlakeBrain and Behavior Discovery Institute, Department of Neurology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA. Electronic address: dblake.mcg@gmail.com.
Augusta University · USDiscovery Institute · USWake Forest University · US

Funding

NEUROMODULATOR INFLUENCES ON PREFRONTAL CORTICAL FUNCTIONR01MH097695 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BLAKE, DAVID T, CONSTANTINIDIS, CHRISTOS · 2013 to 2017
$1.9M
NIH HHS R01MH097695NIMH NIH HHS R01 MH097695
6 · The paper itself

Abstract

Sustained attention is essential in important behaviors in daily life. Many neuropsychiatric disorders are characterized by a compromised ability to sustain attention, making this cognitive domain an important therapeutic target. In this study, we tested a novel method of improving sustained attention. Monkeys were engaged in a continuous performance task (CPT) while the nucleus basalis of Meynert (NB), the main source of cholinergic innervation of the neocortex, was stimulated. Intermittent NB stimulation improved the animals' performance by increasing the hit rate and decreasing the false alarm rate. Administration of the cholinesterase inhibitor donepezil or the muscarinic antagonist scopolamine alone impaired performance, whereas the nicotinic antagonist mecamylamine alone improved performance. Applying NB stimulation while mecamylamine or donepezil were administered impaired CPT performance. Methylphenidate, a monoaminergic psychostimulant, was applied in conjunction with intermittent stimulation as a negative control, as it does not directly modulate cholinergic output. Methylphenidate also improved performance, and it produced further improvement when combined with NB stimulation. The additive effect of the combination suggested NB stimulation altered behavior independently from methylphenidate effects. We conclude that basal forebrain projections contribute to sustained attention, and that intermittent NB stimulation is an effective way of improving performance.

Indexed as

AnimalsAttentionBasal Nucleus of MeynertCentral Nervous System StimulantsCholinesterase InhibitorsDeep Brain StimulationDonepezilMacaca mulattaMaleMecamylamineMethylphenidateMuscarinic AntagonistsNeural PathwaysNicotinic AntagonistsScopolamineCentral Nervous System StimulantsCholinesterase InhibitorsDonepezilMecamylamineMethylphenidateMuscarinic AntagonistsNicotinic AntagonistsScopolamineAcetylcholineDeep brain stimulationNonhuman primateNucleus basalis of meynertSustained attention

Identifiers

PMID29704983
PMCPMC6553880
OpenAlexW2801687739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.