ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2018
Lower C-reactive protein and IL-6 associated with vegetarian diets are mediated by BMI.
Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The effects of consuming a Mediterranean style diet on associated COVID-19 severity biomarkers in obese/overweight adults: A systematic review.Nutrition and health · 2022Pooled it
- Effects of Nutrition Education Program for the Japan Diet on Serum LDL-Cholesterol Concentration in Patients with Dyslipidemia: A Randomized Controlled Trial.Journal of atherosclerosis and thrombosis · 2021Trial
- Knowledge and determinants of plant-based diet adoption among healthcare providers in a Buddhist teaching hospital: a cross-sectional study.Journal of health, population, and nutrition · 2026Article
- Sesame oil improves biomarkers of glycemic control in women with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, controlled clinical trial.BMC nutrition · 2025Article
- Analysis of dietary pattern effects on metabolic risk factors using structural equation modeling.Frontiers in nutrition · 2025Article
- Dietary Patterns, Nutritional Status and Inflammatory Biomarkers in Adolescents from the RPS Birth Cohort Consortium.Nutrients · 2023Article
- Assessment of Oxidant and Antioxidant Status in Prepubertal Children following Vegetarian and Omnivorous Diets.Antioxidants (Basel, Switzerland) · 2023Article
- Healthy plant-based diets improve dyslipidemias, insulin resistance, and inflammation in metabolic syndrome. A narrative review.Advances in nutrition (Bethesda, Md.) · 2023Review
- The Role of the Gut Microbiome in Psoriasis: From Pathogens to Pathology.The Journal of clinical and aesthetic dermatology · 2022Review
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- Effects of Lifestyle Factors on Cognitive Resilience: Commentary on "What This Sunny, Religious Town in California Teaches Us About Living Longer".Translational stroke research · 2020Article
- Vegetarian Epidemiology: Review and Discussion of Findings from Geographically Diverse Cohorts.Advances in nutrition (Bethesda, Md.) · 2019Review
- Hematological parameters and prevalence of anemia in white and British Indian vegetarians and nonvegetarians in the UK Biobank.The American journal of clinical nutrition · 2019Article
- Impact of a 12-month Inflammation Management Intervention on the Dietary Inflammatory Index, inflammation, and lipids.Clinical nutrition ESPEN · 2019Article
- Plant-Based Diets Are Associated With Lower Adiposity Levels Among Hispanic/Latino Adults in the Adventist Multi-Ethnic Nutrition (AMEN) Study.Frontiers in nutrition · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsThe mechanism by which vegetarian diets are associated with less inflammation is not clear. We investigated the role of BMI as a mediator in the relationship between vegetarian diet and concentrations of C-reactive protein (CRP), and the cytokines IL-6, IL-10 and TNF-α. METHODS AND
resultsWe used data from participants of the Adventist Health Study 2 (AHS-2) Calibration (n = 893) and Biological Manifestations of Religion (n = 478) sub-studies. Vegetarian diet variations were determined based on reported intake of animal products assessed by FFQ. Combining all participants, the proportion of non-vegetarians (NVs), partial vegetarians (PVs), lacto-ovo vegetarians (LOVs), and strict vegetarians (SVs) was 44%, 16%, 31%, and 9%, respectively. NV and PV participants were older than other dietary groups, and non-vegetarians had the highest BMI. Mediation analyses supported the mediating effect of BMI in associations of vegetarian diet with CRP (p < 0.001 each for PV, LOV and SV), and with IL-6 (p < 0.05 each for PV, LOV and SV). Mediation by BMI was not evident between vegetarian diet and the biomarkers IL-10 and TNF-α. A direct pathway was significant only in the association between strict vegetarians and CRP (p = 0.017).
conclusionThe lower CRP and IL-6 concentrations among vegetarians may be mediated by BMI.
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Registered trials
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