Evidence map›Paper›PMID 29704858›Full record

ReviewCurrent opinion in cell biology2018

Body builder: from synthetic cells to engineered tissues.

Shiqi Hu, Brenda M Ogle, Ke Cheng

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shiqi HuDepartment of Molecular Biomedical Sciences, Comparative Medicine Institute, NC State University, Raleigh, NC 27607, USA; Joint Department of Biomedical Engineering and Comparative Medicine Institute, UNC-Chapel Hill & NC State University, Raleigh, NC 27607, USA.
Brenda M OgleDepartment of Biomedical Engineering, Stem Cell Institute, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: ogle@umn.edu.
Ke ChengDepartment of Molecular Biomedical Sciences, Comparative Medicine Institute, NC State University, Raleigh, NC 27607, USA; Joint Department of Biomedical Engineering and Comparative Medicine Institute, UNC-Chapel Hill & NC State University, Raleigh, NC 27607, USA. Electronic address: ke_cheng@ncsu.edu.

Funding

Supplement of HL131017: Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytesR01HL131017 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SERPOOSHAN, VAHID, ZHANG, JIANYI · 2016 to 2025
$5.8M
Targeted Nanoparticles for Stem Cell Redirecting and Regenerative MedicineR01HL123920 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2015 to 2023
$4.8M
Extracellular matrix regulation of differentiation via modulation of ILK: application to 3D bioprinting of cardiac tissueR01HL137204 · NHLBI · UNIVERSITY OF MINNESOTA · PI MCALPINE, MICHAEL, OGLE, BRENDA M · 2017 to 2020
$1.7M
Enhancing vascular delivery of stem cells and microparticlesR01HL137093 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL123920NHLBI NIH HHS R01 HL131017NHLBI NIH HHS R01 HL137093NHLBI NIH HHS R01 HL137204
6 · The paper itself

Abstract

It is estimated that 18 Americans die every day waiting for an organ donation. And even if a patient receives the organ that s/he needs, there is still >10% chance that the new organ will not work. The field of tissue engineering and regenerative medicine aims to actively use a patient's own cells, plus biomaterials and factors, to grow specific tissues for replacement or to restore normal functions of that organ, which would eliminate the need for donors and the risk of alloimmune rejection. In this review, we summarized recent advances in fabricating synthetic cells, with a specific focus on their application to cardiac regenerative medicine and tissue engineering. At the end, we pointed to challenges and future directions for the field.

Indexed as

Artificial CellsHumansModels, BiologicalRegenerative MedicineTissue Engineering

Identifiers

PMID29704858
PMCPMC6202268

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.