ArticleCytokine2018
Association between interleukin-6, C-reactive protein and adiponectin with adiposity: Findings from the 1993 pelotas (Brazil) birth cohort at 18 and 22 years.
Article in Cytokine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Leptin, CRP, and adiponectin correlate with body fat percentage in adolescents: systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Pooled it
- Plasma Levels of Triglycerides and IL-6 Are Associated With Weight Regain and Fat Mass Expansion.The Journal of clinical endocrinology and metabolism · 2022Trial
- Adipokine-mediated metabolic responses across BMI in acute myocardial infarction.BMC cardiovascular disorders · 2026Article
- Effects of Vitamin D3 Supplementation on Inflammatory Markers in Overweight and Obese Children and Adolescents: A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Fecal Dysosmobacter spp. concentration is linked to plasma lipidome in insulin-resistant individuals with overweight, obesity and metabolic syndrome.Lipids in health and disease · 2025Article
- Association of inflammatory markers and multimorbidity in young adults: cross-sectional findings from the Pelotas (Brazil) birth cohort, 1993.Cadernos de saude publica · 2025Article
- Insight into the longitudinal relationship between chronic subclinical inflammation and obesity from adolescence to early adulthood: a dual trajectory analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Article
- Adiponectin and Thyroid Cancer: Insight into the Association between Adiponectin and Obesity.Aging and disease · 2021Review
- Developmental trajectories of body mass index from childhood into late adolescence and subsequent late adolescence-young adulthood cardiometabolic risk markers.Cardiovascular diabetology · 2019Article
- Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?BMC musculoskeletal disorders · 2018Article
- Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians.Cytokine · 2018Article
- Physiological markers and multimorbidity: A systematic review.Journal of comorbidityReview
- Social Regulation of the Neural Threat Response Predicts Subsequent Markers of Physical Health.Psychosomatic medicineArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundMost of the literature has shown a direct association between adiposity, interleukin-6 (IL-6) and C-reactive protein (CRP), and an inverse association with adiponectin. The aim of this paper was to assess the association of obesity measurements and IL-6, CRP and adiponectin.
methodsWe performed cross-sectional/longitudinal analysis in the 1993 Birth Cohort in Brazil. Associations between IL-6 (pg/mL), CRP (mg/L) and adiponectin (µg/Ml) with body mass index (BMI), waist circumference (WC), percentage total fat mass (FM) (BODPOD) and trunk FM (DXA) were verified. Four trajectory variables were generated: (a) highest tertile/obesity according to BMI in both follow-ups; (b) highest tertile/obesity only at 18 years; (c) highest tertile/obesity only at 22 years; (d) not in the highest tertile/not obese at both ages.
resultsWe found a direct association for IL-6 and CRP and an inverse association for adiponectin with measures of adiposity. For instance, for females, the highest mean IL-6 and CRP, respectively, was for those who had been in the obese category at 18-22 years (2.49; 3.75), in the highest tertile of WC (2.11; 3.08), in the highest % of FM (1.56; 3.30 l), and in the highest tertile of trunk FM (2.07; 3.26) (p < 0.001 for all these results in the adjusted analysis). Adiponectin showed an inverse association for the above variables, with lower mean values for males than females.
conclusionThere was a longitudinal and direct association between adiposity and IL-6 and CRP, and an inverse association with adiponectin at 22 years.
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