Evidence map›Paper›PMID 29704734›Full record

ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2018

Molecular epidemiology of human adenovirus infections in Denmark, 2011-2016.

Céline Barnadas, Dennis Jelsbak Schmidt, Thea K Fischer, Jannik Fonager

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Construction and application of adenoviral vectors.Molecular therapy. Nucleic acids · 2023
    Review
  7. Article
  8. Article
  9. Review
  10. Non-Human Primate-Derived Adenoviruses for Future Use as Oncolytic Agents?International journal of molecular sciences · 2020
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Céline BarnadasEuropean Public Health Microbiology (EUPHEM) Training Programme, European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden; Virus & Microbiological Special Diagnostics, Infectious Disease Preparedness, Statens Serum Institute, Copenhagen, Denmark.
Dennis Jelsbak SchmidtVirus & Microbiological Special Diagnostics, Infectious Disease Preparedness, Statens Serum Institute, Copenhagen, Denmark.
Thea K FischerVirus & Microbiological Special Diagnostics, Infectious Disease Preparedness, Statens Serum Institute, Copenhagen, Denmark; Department of Infectious Diseases and Centre for Global Health, University of Southern Denmark, Denmark.
Jannik FonagerVirus & Microbiological Special Diagnostics, Infectious Disease Preparedness, Statens Serum Institute, Copenhagen, Denmark. Electronic address: FON@ssi.dk.
Statens Serum Institut · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman adenoviruses (HAdVs) can cause respiratory tract infections, conjunctivitis, diarrhoea and outbreaks have been reported. However, little is known about the disease burden and the molecular epidemiology of HAdV.

objectivesTo retrospectively perform a molecular characterization of HAdV positive samples received at Statens Serum Institut during the period 2011-2016 and to compare this with demographic information, geographic location, sample collection date and type and co-infection with other viral pathogens. STUDY

design152 HAdV positive samples were genotyped by Sanger sequencing of a fragment of the hexon gene using published primers along with a newly developed primer set for enhanced genotyping of HAdV D. Phylogenetic analysis was used for genotyping and genotypes were compared with epidemiological information. In addition, HAdV burden and co-infection was evaluated for samples tested in laboratory analysis packages.

resultsSix out of seven HAdV species were identified and represented by 13 types. Young children (<5 years old) were more likely to be positive for HAdV and co-infections with other gastrointestinal or respiratory viruses were common. Possible outbreaks of ocular infections due to HAdV D could not be confirmed.

conclusionA diverse set of HAdV species were circulating in Denmark in the study period and although possible transmission clusters were identified, this could not be verified with current genotyping methods Young children were commonly affected by HAdV infection and co-infections with other viral pathogens were frequent suggesting a possible underestimation of the real HAdV burden.

Indexed as

GenotypeAdenoviruses, HumanAdenovirus Infections, HumanAdolescentAdultAgedChildChild, PreschoolDenmarkDisease Transmission, InfectiousFemaleHumansInfantMaleMiddle AgedMolecular EpidemiologyGastroenteritis virusHuman adenovirusMolecular epidemiologyPhylogenyRespiratory virus

Identifiers

PMID29704734
PMCPMC7106356
OpenAlexW2802926719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.