ArticleNeuroImage2018
Contribution of systemic vascular effects to fMRI activity in white matter.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 79 citations in OpenAlex.
- Pupil size is linked to opposite signal fluctuations between cortical BOLD and ventricular CSF.NeuroImage · 2026Article
- Functional Magnetic Resonance Imaging Signal Typically Viewed as "Noise" Has Clinical Relevance in Psychiatry.Biological psychiatry global open science · 2026Article
- Distributed fMRI Patterns Coupled to Low-Frequency Cardiorespiratory Dynamics Provide Markers of Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Distributed fMRI patterns coupled to low-frequency cardiorespiratory dynamics provide markers of aging.bioRxiv : the preprint server for biology · 2025Article
- Early menopause is associated with reduced global brain activity.bioRxiv : the preprint server for biology · 2025Article
- Association between low-frequency oscillations in blood pressure variability and brain age derived from neuroimaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of brain amyloid-β accumulation.The journal of prevention of Alzheimer's disease · 2025Observational
- Functional MRI signatures of autonomic physiology in aging.Communications biology · 2025Article
- Systemic physiological "noise" in fMRI has clinical relevance.medRxiv : the preprint server for health sciences · 2025Article
- Alterations in the Glymphatic System and Association with Brain Structure and Cognitive Function in Moyamoya Disease.Translational stroke research · 2025Article
- Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.Cell reports · 2025Article
- Autonomic physiological coupling of the global fMRI signal.Nature neuroscience · 2025Article
- The functional overlap between respiration and global signal and its behavioral relevance.Communications biology · 2025Article
- Functional MRI Signatures of Autonomic Physiology in Aging.bioRxiv : the preprint server for biology · 2025Article
- The Physiological Component of the BOLD Signal: Impact of Age and Heart Rate Variability Biofeedback Training.bioRxiv : the preprint server for biology · 2025Article
- Vasculature-informed spatial smoothing of white matter functional magnetic resonance imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Glymphatic dysfunction in amyotrophic lateral sclerosis: a multimodal MRI investigation of brain-CSF functional and structural dynamics.Frontiers in neuroscience · 2025Article
- Evaluating the dependence of ADC-fMRI on haemodynamics in breath-hold and resting-state conditions.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Resting-State fMRI Reveals the Neural Correlates of Acupuncture in the Treatment of Vascular Cognitive Impairment.Clinical interventions in aging · 2025Review
- The physiological component of the BOLD signal: Impact of age and heart rate variability biofeedback training.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
To investigate a potential contribution of systemic physiology to recently reported BOLD fMRI signals in white matter, we compared photo-plethysmography (PPG) and whole-brain fMRI signals recorded simultaneously during long resting-state scans from an overnight sleep study. We found that intermittent drops in the amplitude of the PPG signal exhibited strong and widespread correlations with the fMRI signal, both in white matter (WM) and in gray matter (GM). The WM signal pattern resembled that seen in previous resting-state fMRI studies and closely tracked the location of medullary veins. Its temporal cross-correlation with the PPG amplitude was bipolar, with an early negative value. In GM, the correlation was consistently positive. Consistent with previous studies comparing physiological signals with fMRI, these findings point to a systemic vascular contribution to WM fMRI signals. The PPG drops are interpreted as systemic vasoconstrictive events, possibly related to intermittent increases in sympathetic tone related to fluctuations in arousal state. The counter-intuitive polarity of the WM signal is explained by long blood transit times in the medullary vasculature of WM, which cause blood oxygenation loss and a substantial timing mismatch between blood volume and blood oxygenation effects. A similar mechanism may explain previous findings of negative WM signals around large draining veins during both task- and resting-state fMRI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.