Evidence map›Paper›PMID 29704283›Full record

ArticleSynapse (New York, N.Y.)2018

Selective dopamine D

Onarae V Rice, Charles R Ashby, Clark Dixon, William Laurenzo, Jason Hayden, Rui Song, Jin Li, Amit K Tiwari, Eliot L Gardner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synapse (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Onarae V RicePsychology Department, Neuroscience Program, Furman University, 3300 Poinsett Highway, Greenville, South Carolina.ORCID 0000-0002-2503-2549
Charles R AshbyDepartment of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, 8000 Utopia Parkway, Jamaica, New York.
Clark DixonPsychology Department, Neuroscience Program, Furman University, 3300 Poinsett Highway, Greenville, South Carolina.
William LaurenzoPsychology Department, Neuroscience Program, Furman University, 3300 Poinsett Highway, Greenville, South Carolina.
Jason HaydenPsychology Department, Neuroscience Program, Furman University, 3300 Poinsett Highway, Greenville, South Carolina.
Rui SongState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Jin LiState Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Amit K TiwariDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio.
Eliot L GardnerNeuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland.
Furman University · USInstitute of Pharmacology · CZNational Institutes of Health · USSt. John's University · USUniversity of Toledo · US

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
Dopamine D3 receptor antagonists for treating drug addiction: Preclinical modelsZIADA000473 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI GARDNER, ELIOT · 2009 to 2020
$3.8M
NIGMS NIH HHS P20 GM103499
6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric syndrome that occurs in individuals exposed to extremely threatening or traumatic events. In both animals and humans, dopamine (DA) function appears to be dysregulated in brain areas involved in the conditioned fear response(s) that underlie PTSD. In this study, we determined the effect of the selective DA D

Indexed as

AnimalsBenzoxazolesDisease Models, AnimalDose-Response Relationship, DrugFecesFreezing Reaction, CatalepticMaleMotor ActivityNitrilesPiperazinesPsychotropic DrugsRandom AllocationRats, Sprague-DawleyReceptors, Dopamine D3Stress Disorders, Post-TraumaticStress, PsychologicalBenzoxazolesDrd3 protein, ratNitrilesPiperazinesPsychotropic DrugsReceptors, Dopamine D3SB 277011TetrahydroisoquinolinesYQA14D3 receptor antagonistsdopaminepost-traumatic stress disorderSB-277011Asingle prolonged stress modelYQA14

Identifiers

PMID29704283
PMCPMC6574226
OpenAlexW2800346848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.