Evidence map›Paper›PMID 29704123›Full record

ArticleLangenbeck's archives of surgery2018

Specific features of colorectal cancer in patients with metabolic syndrome: a matched case-control analysis of 772 patients.

Alban Zarzavadjian Le Bian, Christine Denet, Nicolas Tabchouri, Gianfranco Donatelli, Philippe Wind, Christophe Louvet, Mostefa Bennamoun, Christos Christidis, Thierry Perniceni, David Fuks and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Role of HGF/c-Met in the treatment of colorectal cancer with liver metastasis.Journal of biochemical and molecular toxicology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Alban Zarzavadjian Le BianDepartment of Digestive Surgery, CHU Avicenne, Assistante Publique - Hôpitaux de Paris, Université Paris XIII, 125, rue de Stalingrad, 93000, Bobigny, France. spleen2008@live.fr.ORCID http://orcid.org/0000-0002-7384-1148
Christine DenetDepartment of Digestive Disease, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France.
Nicolas TabchouriDepartment of Digestive Disease, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France.
Gianfranco DonatelliDepartment of Digestive Endoscopy, Hôpital Privé de la Poterne des Peupliers, 8 place de l'Abbé Hénocque, 75013, Paris, France.
Philippe WindDepartment of Digestive Surgery, CHU Avicenne, Assistante Publique - Hôpitaux de Paris, Université Paris XIII, 125, rue de Stalingrad, 93000, Bobigny, France.
Christophe LouvetDepartment of Oncology, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France.
Mostefa BennamounDepartment of Oncology, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France.
Christos ChristidisDepartment of Digestive Disease, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France.
Thierry PerniceniDepartment of Digestive Disease, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France.
David FuksDepartment of Digestive Disease, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France.
Brice GayetDepartment of Digestive Disease, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France.
Institute Mutualiste Montsouris · FRDélégation Paris 5 · FRHôpital Privé Jacques Cartier · FRUniversité Sorbonne Paris Nord · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough association between colorectal cancer (CRC) and metabolic syndrome (MetS) is established, specific features of CRC arising in patients presenting with MetS have not been clearly identified.

methodAll patients who underwent colectomy for CRC from January 2005 to December 2014 at Institut Mutualiste Montsouris were identified from a prospectively collected database and characteristics were compared in the entire population and in a 1:2 matched case-control analysis [variables on which matching was performed were CRC localization (right- or left-sided) and AJCC stage (0 to IV)].

resultsOut of the 772 identified patients, 98 (12.7%) presented with MetS. Entire population analysis revealed that CRC associated with MetS was more frequent in men (71.4 vs. 47.8%, p < 0.001), more often right-sided (71.4 vs. 50.4%, p < 0.001) and presented with less synchronous liver metastasis (4.1 vs. 8.7%, p = 0.002). Case-control analysis confirmed the gender association (p < 0.001) and showed HNPCC (p < 0.001) and history family of CRC (p = 0.010) to be significantly more frequent in Non-MetS patients.

conclusionsCRC associated with MetS is more frequent in men, more often right-sided, and presents with fewer synchronous metastasis. Further investigations should be designed in order to confirm these results and to enhance our knowledge of carcinogenesis related to MetS.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesColectomyColorectal NeoplasmsFemaleHumansLiver NeoplasmsMaleMetabolic SyndromeMiddle AgedNeoplasm StagingSex FactorsSurvival AnalysisCarcinogenesisColectomyColorectal cancerMetabolic syndrome

Identifiers

PMID29704123
OpenAlexW2802740166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.