Evidence map›Paper›PMID 29704100›Full record

ArticleHeart and vessels2018

Downregulation of miR-34a promotes endothelial cell growth and suppresses apoptosis in atherosclerosis by regulating Bcl-2.

Gang Su, Guangli Sun, Hai Liu, Liliang Shu, Zhenxing Liang

Abstract read
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

  1. Na/K-ATPase Signaling in Adipocytes Promotes Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  2. Review
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  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. MicroRNA-34a: the bad guy in age-related vascular diseases.Cellular and molecular life sciences : CMLS · 2021
    Review
  16. Review
  17. MicroRNA regulation of cholesterol metabolism.Annals of the New York Academy of Sciences · 2021
    Review
  18. Article
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gang SuDepartment of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 453100, China.
Guangli SunDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou, 453100, China. sunguangli126@163.com.ORCID http://orcid.org/0000-0002-4240-4586
Hai LiuDepartment of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 453100, China.
Liliang ShuDepartment of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 453100, China.
Zhenxing LiangDepartment of Cardiac Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 453100, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

Henan Provincial Department of Education research project 162102310550
6 · The paper itself

Abstract

Several miRNAs have been demonstrated to be involved in endothelial dysfunction during atherosclerosis (AS). However, the detailed roles and underlying mechanisms of miR-34a in AS-associated endothelial cell apoptosis are far from being addressed. Apolipoprotein E-deficient (ApoE

Indexed as

ApoptosisDown-RegulationGene Expression RegulationAnimalsApolipoproteins EAtherosclerosisbcl-X ProteinBlotting, WesternCells, CulturedCell SurvivalDisease Models, AnimalEndothelial CellsFlow CytometryImmunoprecipitationMaleMiceApolipoproteins EBcl2l1 protein, mousebcl-X ProteinMicroRNAsMIRN34a microRNA, mouseRNAApoE−/− miceAtherosclerosisBcl-2Endothelial cellsHigh-fat dietmiR-34aOxidized low-density lipoprotein

Identifiers

PMID29704100
OpenAlexW2800921832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.