Evidence map›Paper›PMID 29704077›Full record

SynthesisNeuropsychology review2018

Executive Functions in Children and Adolescents with Turner Syndrome: A Systematic Review and Meta-Analysis.

Claire Mauger, Céline Lancelot, Arnaud Roy, Régis Coutant, Nicole Cantisano, Didier Le Gall

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuropsychology review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06544473 phase4recruitingnot on this mapstarted 2021, after this paper: background citation

Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome - A Randomized Study

TypeinterventionalSponsorAarhus University HospitalRan2021 to 2026Enrolled50ConditionsTurner Syndrome, Hypogonadism, Ovarian, Hormone Replacement TherapyArms17-beta estradiol
NCT06570460 phase4recruitingnot on this mapstarted 2021, after this paper: background citation

Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome - A Randomized Trial

TypeinterventionalSponsorAarhus University HospitalRan2021 to 2026Enrolled50ConditionsTurner Syndrome, Hypogonadism, Ovarian, Hormone Replacement TherapyArms17-beta estradiol
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Empathic Accuracy in Adolescent Girls with Turner Syndrome.Journal of autism and developmental disorders · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Pieces of evidences of reliability of the Brazilian version of the Child Executive Functions Battery (CEF-B).Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2021
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Reversal Learning Performance in the XYFrontiers in behavioral neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claire MaugerLaboratoire de Psychologie des Pays de la Loire (EA 4638), University of Angers, Angers, France. claire.mauger@univ-angers.fr.ORCID 0000-0001-6896-7929
Céline LancelotLaboratoire de Psychologie des Pays de la Loire (EA 4638), University of Angers, Angers, France.
Arnaud RoyLaboratoire de Psychologie des Pays de la Loire (EA 4638), University of Angers, Angers, France.
Régis CoutantDepartment of Pediatrics, Angers University Hospital, Angers, France.
Nicole CantisanoLaboratoire de Psychologie des Pays de la Loire (EA 4638), University of Angers, Angers, France.
Didier Le GallLaboratoire de Psychologie des Pays de la Loire (EA 4638), University of Angers, Angers, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Turner syndrome (TS) is a genetic disorder, affecting 1/2500 to 1/3000 live female births, induced by partial or total deletion of one X chromosome. The neurocognitive profile of girls with TS is characterized by a normal Verbal IQ and weaknesses in visual-spatial, mathematics, and social cognitive domains. Executive functions (EFs) impairments have also been reported in these young patients. However, methodological differences across studies do not allow determination of which EFs are impaired and what is the magnitude of these impairments. The aim of this review was to clarify the EF profile of children and adolescents with TS. Sixteen samples, from thirteen studies, were included in the current meta-analysis. EFs measures used in these studies were classified into working memory, inhibitory control, cognitive flexibility, or higher-order EFs tasks in accordance with Diamond's model, Annual Review of Psychology, 64, 135-168 (2013). Results confirmed that girls with TS had significant executive impairments with effect sizes varying from small (inhibitory control) to medium (cognitive flexibility) and large (working memory, higher-order EFs). Analyses by task revealed that cognitive inhibition may be more impaired than the other inhibitory control abilities. Heterogeneity across cognitive flexibility measures was also highlighted. Between-sample heterogeneity was observed for three tasks and the impact of participants' characteristics on EFs was discussed. This meta-analysis confirms the necessity to assess, in patients living with TS, each EF by combining both visual and verbal tasks. Results also underline that, when studying girls with TS' executive profile, it is important to explore the impact of moderator variables, such as IQ, parental socio-economic status, TS karyotype, psychiatric comorbidities, and hormonal treatment status.

Indexed as

Executive FunctionAdolescentChildHumansTurner SyndromeExecutive functionsFlexibilityInhibitionMeta-analysisTurner syndromeWorking memory

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.