Evidence map›Paper›PMID 29704052›Full record

ReviewCurrent genetics2018

Regulation of kinetochore configuration during mitosis.

Karthik Dhatchinamoorthy, Mark Mattingly, Jennifer L Gerton

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karthik DhatchinamoorthyStowers Institute for Medical Research, Kansas City, USA.
Mark MattinglyStowers Institute for Medical Research, Kansas City, USA.
Jennifer L GertonStowers Institute for Medical Research, Kansas City, USA. jeg@stowers.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Successful proliferation and function of an organism relies on the equal segregation of its genetic material during cell division. Duplicate sister chromatids need to accurately segregate at mitosis. Precise segregation depends on a multicomplex protein structure called the kinetochore. The kinetochore assembles at centromeres and attaches to microtubules to segregate sister chromatids. Even though the kinetochore structure was first observed nearly a century ago, many aspects of the regulation, function and assembly of this large 100 + protein structure remain to be determined. Improved microscopy and proteomics techniques over the years have helped to reveal the structure, composition and localization of sub-modules of the kinetochore. Recent work suggests that the configuration of the kinetochore is plastic, with extra submodules being added during anaphase to support microtubule tracking and chromosome segregation. We discuss our perspective of how this process might be regulated.

Indexed as

AnimalsChromatidsChromosome SegregationHumansKinetochoresMitosisAnaphaseDam1 complexKinetochoreMicrotubuleMitosisNdc80 complex

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.