ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Cognitive deficit in methamphetamine users relative to childhood academic performance: link to cortical thickness.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Methamphetamine hijacks chaperone-mediated autophagy to degrade GPX4, driving ferroptosis-precipitated cognitive decline and addictive pathogenesis.Acta neuropathologica communications · 2026Article
- Extensive frontal cortex abnormalities and cognitive impairment in methamphetamine use disorder: a comprehensive 3T structural MRI analysis.BMC psychiatry · 2026Article
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Differences and similarities between the genetic architecture of lifetime substance use across different substances.Psychological medicine · 2025Article
- Dopamine D2/D3 receptor availability and working memory in stimulant use disorder.The American journal of drug and alcohol abuse · 2025Article
- Cognitive functions among Saudi patients with methamphetamine and cannabis use disorder.Frontiers in psychiatry · 2025Article
- Modulation of dlPFC function and decision-making capacity by repetitive transcranial magnetic stimulation in methamphetamine use disorder.Translational psychiatry · 2024Article
- Cortical thickness and related depressive symptoms in early abstinence from chronic methamphetamine use.Addiction biology · 2022Article
- Denial and Diagnosis of Methamphetamine Dependence Severity.Substance abuse : research and treatment · 2022Article
- Cognition during active methamphetamine use versus remission.Journal of clinical and experimental neuropsychology · 2021Article
- CYP2D6 genotype may moderate measures of brain structure in methamphetamine users.Addiction biology · 2021Article
- Age Influences Loss Aversion Through Effects on Posterior Cingulate Cortical Thickness.Frontiers in neuroscience · 2021Article
- Executive function moderates naltrexone effects on methamphetamine-induced craving and subjective responses.The American journal of drug and alcohol abuse · 2020Article
- Adverse effect of catechol-O-methyltransferase (COMT) Val158Met met/met genotype in methamphetamine-related executive dysfunction.Addictive behaviors · 2019Article
- Cognition and addiction .Dialogues in clinical neuroscience · 2019Review
- qEEG Measures of Attentional and Memory Network Functions in Medical Students: Novel Targets for Pharmacopuncture to Improve Cognition and Academic Performance.Journal of pharmacopuncture · 2019Article
- Effects of Naltrexone on Large-Scale Network Interactions in Methamphetamine Use Disorder.Frontiers in psychiatry · 2019Article
- Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions.Frontiers in psychiatry · 2019Article
- Differences in rates of impairment in adults who use methamphetamine using two sets of demographically corrected norms.Applied neuropsychology. AdultArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Individuals with cognitive problems may be predisposed to develop substance use disorders; therefore, differences in cognitive function between methamphetamine users and control participants may be attributable to premorbid factors rather than methamphetamine use. The goal of this study was to clarify the extent to which this is the case. Childhood academic transcripts were obtained for 37 methamphetamine-dependent adults and 41 control participants of similar educational level and premorbid IQ. Each participant completed a comprehensive cognitive battery and received a structural magnetic resonance imaging scan. Data from control participants and linear regression were used to develop a normative model to describe the relationship between childhood academic performance and scores on the cognitive battery. Using this model, cognitive performance of methamphetamine users was predicted from their premorbid academic scores. Results indicated that methamphetamine users' childhood grade point average was significantly lower than that of the control group (p < 0.05). Further, methamphetamine users' overall cognitive performance was lower than was predicted from their grade point average prior to methamphetamine use (p = 0.001), with specific deficits in attention/concentration and memory (ps < 0.01). Memory deficits were associated with lower whole-brain cortical thickness (p < 0.05). Thus, in addition to having an apparent premorbid weakness in cognition, methamphetamine users exhibit subsequent cognitive function that is significantly lower than premorbid estimates would predict. The results support the view that chronic methamphetamine use causes a decline in cognition and/or a failure to develop normative cognitive abilities, although aside from methamphetamine use per se, other drug use and unidentified factors likely contribute to the observed effects.
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