ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task.NeuroImage · 2022Pooled it
- Impaired Learning From Negative Feedback in Stimulant Use Disorder: Dopaminergic Modulation.The international journal of neuropsychopharmacology · 2021Trial
- Brain Architecture of Punishment Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neuroanatomy reflects individual variability in impulsivity in youth.Molecular psychiatry · 2026Article
- Involvement of the dorsal raphe serotonin system in basal and punished heroin self-administration and stress-induced reinstatement in male and female rats.Psychopharmacology · 2026Article
- Disinhibition of ventral tegmental area during initial punishment learning causes enduring punishment insensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Reinforcement learning impairment in individuals with euthymic bipolar I disorder with a history of psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Instrumental learning enhances the intrinsic excitability of basal amygdala projection neurons.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- Validation of the Polish adaptation of the Students' Punishment Sensitivity Scale in an educational context.Frontiers in psychology · 2026Review
- Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Risk reshapes amygdala representation of choice.bioRxiv : the preprint server for biology · 2025Article
- Current interpretations of the I-PACE model of behavioral addictions.Journal of behavioral addictions · 2025Review
- Remission from addiction: erasing the wrong circuits or making new ones?Nature reviews. Neuroscience · 2025Review
- Role of serotonin neurons in the dorsal raphe nucleus in heroin self-administration and punishment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Striosome Circuitry Stimulation Inhibits Striatal Dopamine Release and Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood.Neurobiology of learning and memory · 2025Article
- Orbitofrontal and Prelimbic Cortices Serve Complementary Roles in Adapting Reward Seeking to Learned Anxiety.Biological psychiatry · 2024Article
- Nutritional Modulation of the Gut-Brain Axis: A Comprehensive Review of Dietary Interventions in Depression and Anxiety Management.Metabolites · 2024Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Punishment involves learning about the relationship between behavior and its adverse consequences. Punishment is fundamental to reinforcement learning, decision-making and choice, and is disrupted in psychiatric disorders such as addiction, depression, and psychopathy. However, little is known about the brain mechanisms of punishment and much of what is known is derived from study of superficially similar, but fundamentally distinct, forms of aversive learning such as fear conditioning and avoidance learning. Here we outline the unique conditions that support punishment, the contents of its learning, and its behavioral consequences. We consider evidence implicating GABA and monoamine neurotransmitter systems, as well as corticostriatal, amygdala, and dopamine circuits in punishment. We show how maladaptive punishment processes are implicated in addictions, impulse control disorders, psychopathy, anxiety, and depression and argue that a better understanding of the cellular, circuit, and cognitive mechanisms of punishment will make important contributions to next generation therapeutic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.