ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Cortical inhibitory markers of lifetime suicidal behavior in depressed adolescents.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04502758 (A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation Associated With Major Depressive Disorder), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation Associated With Major Depressive Disorder
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Interventions for suicidal and self-injurious related behaviors in adolescents with psychiatric disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- A Systematic Review of Long-Interval Intracortical Inhibition as a Biomarker in Neuropsychiatric Disorders.Frontiers in psychiatry · 2021Pooled it
- Transcranial magnetic stimulation neurophysiology of patients with major depressive disorder: a systematic review and meta-analysis.Psychological medicine · 2021Pooled it
- Neurostructural Differences in Adolescents With Treatment-Resistant Depression and Treatment Effects of Transcranial Magnetic Stimulation.The international journal of neuropsychopharmacology · 2022Trial
- Left prefrontal transcranial magnetic stimulation for treatment-resistant depression in adolescents: a double-blind, randomized, sham-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder: From Bench to Bedside-A Scoping Review of Neurobiological Mechanisms and Clinical Translation.Bioengineering (Basel, Switzerland) · 2026Review
- Cortical high-threshold and low-activation characteristics in adolescent depression: a cross-age differential analysis.Frontiers in psychiatry · 2026Article
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Exploring Applications of Transcranial Magnetic Stimulation in Child and Adolescent Psychiatry: A Narrative Review.Journal of clinical medicine · 2025Review
- GABAA Receptor Availability in Relation to Cortical Excitability in Depressed and Healthy: A Positron Emission Tomography and Transcranial Magnetic Stimulation Study.Neuropsychobiology · 2024Article
- Associations of physical fitness with cortical inhibition and excitation in adolescents and young adults.Frontiers in neuroscience · 2024Article
- Advances and Applications of Brain Organoids.Neuroscience bulletin · 2023Review
- Article
- Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C.EMBO molecular medicine · 2023Article
- Article
- GABACurrent topics in behavioral neurosciences · 2022Article
- Structural-functional decoupling predicts suicide attempts in bipolar disorder patients with a current major depressive episode.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Multilayer MEG functional connectivity as a potential marker for suicidal thoughts in major depressive disorder.NeuroImage. Clinical · 2020Article
- Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder.Journal of psychiatric research · 2019Article
- Preliminary evidence of an association between increased cortical inhibition and reduced suicidal ideation in adolescents treated for major depression.Journal of affective disorders · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Although suicide is the second-leading cause of death in adolescents and young adults worldwide, little progress has been made in developing reliable biological markers of suicide risk and suicidal behavior. Converging evidence suggests that excitatory and inhibitory cortical processes mediated by the neurotransmitters glutamate and γ-aminobutyric acid (GABA) are dysregulated in suicidal individuals. This study utilized single- and paired-pulse transcranial magnetic stimulation (TMS) to assess excitatory and inhibitory cortical functioning in healthy control adolescents (n = 20), depressed adolescents without any history of suicidal behavior ("Depressed", n = 37), and depressed adolescents with lifetime history of suicidal behavior ("Depressed+SB", n = 17). In a fixed-effects general linear model analysis, with age, sex, and depression severity as covariates, no significant group main effects emerged for resting motor threshold, intracortical facilitation, short-interval intracortical inhibition, or cortical silent period. However, group main effects were significant for long-interval intracortical inhibition (LICI) at interstimulus intervals (ISIs) of 100 ms and 150 ms, but not 200 ms. Depressed+SB adolescents demonstrated impaired LICI compared to healthy control and Depressed adolescents, while healthy control and Depressed participants did not differ in LICI. Multiple linear robust regression revealed significant positive linear relationships between lifetime suicidal behavior severity and impairment in LICI at 100-ms and 150-ms ISIs. In a post hoc receiver operating characteristic analysis, LICI significantly discriminated Depressed from Depressed+SB youth in 100-ms and 150-ms paradigms. These findings suggest that GABA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.