Evidence map›Paper›PMID 29703987›Full record

ArticleScientific reports2018

Staphylococcus aureus enterotoxins modulate IL-22-secreting cells in adults with atopic dermatitis.

Raquel Leao Orfali, Luanda Mara da Silva Oliveira, Josenilson Feitosa de Lima, Gabriel Costa de Carvalho, Yasmim Alefe Leuzzi Ramos, Natalli Zanete Pereira, Naiura Vieira Pereira, Mariana Colombini Zaniboni, Mirian Nacagami Sotto, Alberto José da Silva Duarte and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Keratinocytes: pleiotropic orchestrators of cutaneous immunity and Inflammation - Emerging therapeutic paradigms in dermatological pathologies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  2. Review
  3. Allergen-specific circulating CLAFrontiers in immunology · 2025
    Article
  4. State of the Art on the Role ofMicroorganisms · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis.JID innovations : skin science from molecules to population health · 2022
    Review
  14. Exploring the Role ofToxins · 2022
    Review
  15. Immunomodulatory Role ofPathogens (Basel, Switzerland) · 2022
    Review
  16. The infectious complications of atopic dermatitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Raquel Leao OrfaliUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil. raquelleao@hotmail.com.ORCID 0000-0002-2807-1404
Luanda Mara da Silva OliveiraUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Josenilson Feitosa de LimaUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Gabriel Costa de CarvalhoUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Yasmim Alefe Leuzzi RamosUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Natalli Zanete PereiraUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Naiura Vieira PereiraUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Mariana Colombini ZaniboniUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Mirian Nacagami SottoUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Alberto José da Silva DuarteUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Maria Notomi SatoUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Valeria AokiUniversity of Sao Paulo Medical School, Department of Dermatology, Laboratory of Dermatology and Immunode-ficiencies (LIM-56), Sao Paulo, SP, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by skin colonization by Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of antimicrobial peptide (AMP) production. We aimed to evaluate the impact of staphylococcal enterotoxins on the Tc22/Th22 induction in the peripheral blood of AD patients and on CD4

Indexed as

AdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDermatitis, AtopicEnterotoxinsFemaleHumansImmunologic FactorsInterleukin-22InterleukinsMaleMiddle AgedStaphylococcal Skin InfectionsYoung AdultEnterotoxinsImmunologic FactorsInterleukin-22Interleukins

Identifiers

PMID29703987
PMCPMC5923268
OpenAlexW2806742771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.