Evidence map›Paper›PMID 29703961›Full record

ArticleJournal of human genetics2018

Genetic variants in chemokine CC subfamily genes influence hepatitis C virus viral clearance.

Yinan Yao, Ming Yue, Feng Zang, Mei Liu, Haozhi Fan, Lingyun Zhuo, Jingjing Wu, Xueshan Xia, Yue Feng, Peng Huang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yinan YaoDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Ming YueDepartment of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Feng ZangDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Mei LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Haozhi FanDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Lingyun ZhuoDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Jingjing WuDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Xueshan XiaFaculty of Life Science and Technology, Kunming University of Science and Technology of Science and Technology, Yunnan, 650500, China.
Yue FengFaculty of Life Science and Technology, Kunming University of Science and Technology of Science and Technology, Yunnan, 650500, China.
Peng HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. huangpeng@njmu.edu.cn.
Rongbin YuDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. rongbinyu@njmu.edu.cn.
Nanjing Medical University · CNKunming University of Science and Technology · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemokine genes may influence both hepatitis C virus (HCV) spontaneous clearance in acute infection and treatment response in chronic infection. We conducted this study to evaluate whether the genetic variants in several CC family genes influence HCV spontaneous clearance and treatment response. The current research genotyped eight SNPs, including CCR1 rs3733096, rs13096371, CCR5 rs746492, rs1800874, CCL3 rs1130371, CCL5 rs3817656, CCL8 rs1133763, CCL14 rs854625, to explore their associations with HCV spontaneous clearance and response to treatment in two populations. We identified that the CCR1 rs3733096 (dominant model: adjusted OR = 2.29, 95% CI = 1.49-3.53, additive model: adjusted OR = 2.21, 95% CI = 1.50-3.25) and CCL5 rs3817656 (dominant model: OR = 1.37, 95% CI = 1.10-1.70, additive model: OR = 1.33, 95% CI = 1.12-1.58) were associated with HCV spontaneous clearance in Chinese Han population, while we found no association with treatment response. Moreover, the expression quantitative trait loci (eQTL) analysis showed that the risk alleles of rs3817656 were significantly associated with downregulated expression of CCL5 in whole blood (P < 0.001). The polymorphism of CCR1 rs3733096 and CCL5 rs3817656 are associated with spontaneous clearance of HCV in Chinese Han population.

Indexed as

Models, GeneticPolymorphism, Single NucleotideAdultAgedAllelesAntiviral AgentsAsian PeopleChemokine CCL5Cross-Sectional StudiesFemaleGene ExpressionHepacivirusHepatitis C, ChronicHumansMaleMiddle AgedAntiviral AgentsCCL5 protein, humanCCR1 protein, humanChemokine CCL5Protein IsoformsReceptors, CCR1

Identifiers

PMID29703961
OpenAlexW2802948169

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.