ArticleNature communications2018
A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
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- Advancing Key Gaps in the Knowledge ofFrontiers in cellular and infection microbiology · 2022Review
- Gametogenesis inFrontiers in cellular and infection microbiology · 2022Review
- Uncovering a Cryptic Site of Malaria Pathogenesis: Models to Study Interactions BetweenFrontiers in cellular and infection microbiology · 2022Review
- Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis.PLoS pathogens · 2021Article
- The global burden of Plasmodium vivax malaria is obscure and insidious.PLoS medicine · 2021Article
- Oral Therapy Using a Combination of Nanotized Antimalarials and Immunomodulatory Molecules Reduces Inflammation and Prevents Parasite Induced Pathology in the Brain and Spleen ofFrontiers in immunology · 2021Article
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3 authors at 1 institution in 1 country.
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Abstract
Blood stage human malaria parasites may exploit erythropoietic tissue niches and colonise erythroid progenitors; however, the precise influence of the erythropoietic environment on fundamental parasite biology remains unknown. Here we use quantitative approaches to enumerate Plasmodium infected erythropoietic precursor cells using an in vivo rodent model of Plasmodium berghei. We show that parasitised early reticulocytes (ER) in the major sites of haematopoiesis establish a cryptic asexual cycle. Moreover, this cycle is characterised by early preferential commitment to gametocytogenesis, which occurs in sufficient numbers to generate almost all of the initial population of circulating, mature gametocytes. In addition, we show that P. berghei is less sensitive to artemisinin in splenic ER than in blood, which suggests that haematopoietic tissues may enable origins of recrudescent infection and emerging resistance to antimalarials. Continuous propagation in these sites may also provide a mechanism for continuous transmission and infection in malaria endemic regions.
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