ArticleScientific reports2018
Three-dimensional Cardiomyocytes Structure Revealed By Diffusion Tensor Imaging and Its Validation Using a Tissue-Clearing Technique.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Voxel-scale diffusion tensor phenomapping of the healthy and pressure-overloaded human heart.Nature biomedical engineering · 2026Article
- Mesenchymal Stromal Cells Improve Postoperative Cardiac Dysmaturation in a Juvenile Porcine Model.Journal of the American Heart Association · 2026Article
- Platelet derived growth factor-AB modulates post-infarct myocardium leading to extended improvement in cardiac function.NPJ Regenerative medicine · 2025Article
- EchoFM: Foundation Model for Generalizable Echocardiogram Analysis.IEEE transactions on medical imaging · 2025Article
- The Role and Potential Mechanisms of Rehabilitation Exercise Improving Cardiac Remodeling.Journal of cardiovascular translational research · 2024Review
- Next-Generation Cardiac Magnetic Resonance Imaging Techniques for Characterization of Myocardial Disease.Current treatment options in cardiovascular medicine · 2024Article
- Light-Sheet Imaging to Reveal Cardiac Structure in Rodent Hearts.Journal of visualized experiments : JoVE · 2024Article
- Review
- Diffusion-weighted imaging and diffusion tensor imaging of the heartPostepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Review
- Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts.APL bioengineering · 2022Article
- Exercise-induced CITED4 expression is necessary for regional remodeling of cardiac microstructural tissue helicity.Communications biology · 2022Article
- Comparison of interpolation methods of predominant cardiomyocyte orientation from in vivo and ex vivo cardiac diffusion tensor imaging data.NMR in biomedicine · 2022Article
- Of form and function: Early cardiac morphogenesis across classical and emerging model systems.Seminars in cell & developmental biology · 2021Review
- A simple optical tissue clearing pipeline for 3D vasculature imaging of the mediastinal organs in mice.International journal of experimental pathology · 2021Article
- Review
- Magnetic Resonance-Based Characterization of Myocardial Architecture.Heart failure clinics · 2021Review
- Cardiac multi-scale investigation of the right and left ventricleCardiovascular diagnosis and therapy · 2020Review
- Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response.Nature communications · 2019Article
- Recent Advances in Cardiac Magnetic Resonance Imaging.Korean circulation journal · 2019Review
- Imaging the Microstructure of the Human Fetal Heart.Circulation. Cardiovascular imaging · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
We characterized the microstructural response of the myocardium to cardiovascular disease using diffusion tensor imaging (DTI) and performed histological validation by intact, un-sectioned, three-dimensional (3D) histology using a tissue-clearing technique. The approach was validated in normal (n = 7) and ischemic (n = 8) heart failure model mice. Whole heart fiber tracking using DTI in fixed ex-vivo mouse hearts was performed, and the hearts were processed with the tissue-clearing technique. Cardiomyocytes orientation was quantified on both DTI and 3D histology. Helix angle (HA) and global HA transmurality (HAT) were calculated, and the DTI findings were confirmed with 3D histology. Global HAT was significantly reduced in the ischemic group (DTI: 0.79 ± 0.13°/% transmural depth [TD] and 3D histology: 0.84 ± 0.26°/%TD) compared with controls (DTI: 1.31 ± 0.20°/%TD and 3D histology: 1.36 ± 0.27°/%TD, all p < 0.001). On direct comparison of DTI with 3D histology for the quantitative assessment of cardiomyocytes orientation, significant correlations were observed in both per-sample (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.