Evidence map›Paper›PMID 29703899›Full record

ArticleScientific reports2018

Mitochondria-targeted Probes for Imaging Protein Sulfenylation.

Reetta J Holmila, Stephen A Vance, Xiaofei Chen, Hanzhi Wu, Kirtikar Shukla, Manish S Bharadwaj, Jade Mims, Zack Wary, Glen Marrs, Ravi Singh and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Visible and NIR light photoactivatableRSC medicinal chemistry · 2023
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  4. [Redox biology · 2022
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  7. Article
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  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Dual-ReactivityJournal of the American Chemical Society · 2019
    Article
  15. Article
  16. Mass Spectrometry in Advancement of Redox Precision Medicine.Advances in experimental medicine and biology · 2019
    Review
  17. Peroxiredoxins in Cancer and Response to Radiation Therapies.Antioxidants (Basel, Switzerland) · 2019
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Reetta J HolmilaDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
Stephen A VanceDepartment of Chemistry, Wake Forest University, Winston-Salem, NC, 27109, USA.
Xiaofei ChenDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
Hanzhi WuDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
Kirtikar ShuklaDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
Manish S BharadwajDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
Jade MimsDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
Zack WaryDepartment of Chemistry, Wake Forest University, Winston-Salem, NC, 27109, USA.
Glen MarrsDepartment of Biology, Wake Forest University, Winston-Salem, NC, 27109, USA.
Ravi SinghDepartment of Cancer Biology, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.ORCID 0000-0003-0750-1804
Anthony J MolinaDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
Leslie B PooleDepartment of Biochemistry, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA.
S Bruce KingDepartment of Chemistry, Wake Forest University, Winston-Salem, NC, 27109, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA. cfurdui@wakehealth.edu.
Wake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Integrative Lipid Metabolism, Inflammation, and Chronic DiseasesT32HL091797 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PARKS, JOHN S · 2008 to 2017
$1.8M
Development of a novel therapeutic agent that exploits specific vulnerabilities in claudin low breast cancerR01CA207222 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SINGH, RAVI N · 2017 to 2021
$1.7M
New Oxidation-Sensing Probes to Evaluate Mitochondrial Dysfunction in Lung InjuryR33ES025645 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FURDUI, CRISTINA MARIA, KING, S BRUCE · 2017 to 2019
$1.5M
New Reagents for Tracking Protein Oxidation in Cells by MS and Imaging MethodsR33CA177461 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FURDUI, CRISTINA MARIA, POOLE, LESLIE B · 2013 to 2015
$1.0M
New Oxidation-Sensing Probes to Evaluate Mitochondrial Dysfunction in Lung InjuryR21ES025645 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FURDUI, CRISTINA MARIA, KING, S BRUCE · 2015 to 2016
$428k
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA207222NCI NIH HHS R33 CA177461NHLBI NIH HHS T32 HL091797NIEHS NIH HHS R21 ES025645NIEHS NIH HHS R33 ES025645
6 · The paper itself

Abstract

Mitochondrial reactive oxygen species (ROS) are essential regulators of cellular signaling, metabolism and epigenetics underlying the pathophysiology of numerous diseases. Despite the critical function of redox regulation in mitochondria, currently there are limited methods available to monitor protein oxidation in this key subcellular organelle. Here, we describe compounds for imaging sulfenylated proteins in mitochondria: DCP-NEt

Indexed as

Protein Processing, Post-TranslationalA549 CellsCytological TechniquesHumansIndicators and ReagentsMitochondriaMitochondrial ProteinsMolecular ProbesOxidation-ReductionStaining and LabelingSulfenic AcidsIndicators and ReagentsMitochondrial ProteinsMolecular ProbesSulfenic Acids

Identifiers

PMID29703899
PMCPMC5923234
OpenAlexW2806997897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.