ArticleNature communications2018
The Ustilago maydis repetitive effector Rsp3 blocks the antifungal activity of mannose-binding maize proteins.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72 citing papers in PubMed, 142 citations in OpenAlex.
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- Lysine crotonylation enhances fungal effector activity and promotes invasion of host plants.Plant communications · 2026Article
- A fungal nuclease effector subverts the chloroplast genome and triggers cell death to promote infection.Nature plants · 2026Article
- Identification of theBiology · 2026Article
- Pathogenic fungus Ustilago maydis exploits the lateral root regulators to induce pluripotency in maize shoots.The New phytologist · 2026Article
- Protein Extraction Methods for Ustilago maydis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases inComputational and structural biotechnology journal · 2026Article
- Studying Cell Wall-Associated Effectors in U. maydis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Immunodetection of Cell-Surface-Associated Proteins in Ustilago maydis and Infected Maize Leaves.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Induction of Ustilago maydis Appressorium and Filamentation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Apoplastic Fluid Collection/Analysis of Ustilago maydis-Infected Maize Leaves.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Pathogenesis, Host Resistance and Integrated Management of Sugarcane Smut Caused by Sporisorium scitamineum: A Comprehensive Review.Molecular plant pathology · 2025Review
- Chromosome-level comparative genomics and host-specific fungal transcriptomics uncover adaptive virulence strategies in the sugarcane smut pathogen.BMC genomics · 2025Article
- Cysteine-rich receptor-like secreted protein 1 promotes intercellular infection and enhances nodulation inHorticulture research · 2025Article
- More questions than answers: insights into potential cysteine-rich receptor-like kinases redox signalling in Arabidopsis.The Plant journal : for cell and molecular biology · 2025Review
- Structural and Functional Analysis of the Lectin-like Protein Llp1 Secreted byJournal of fungi (Basel, Switzerland) · 2025Article
- Decoding sugarcane smut: the role of effector SsEF83 in fungal virulence and plant interaction.Frontiers in microbiology · 2025Article
- The cysteine-rich virulence factor NipA of Arthrobotrys flagrans interferes with cuticle integrity of Caenorhabditis elegans.Nature communications · 2024Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To cause disease in maize, the biotrophic fungus Ustilago maydis secretes a large arsenal of effector proteins. Here, we functionally characterize the repetitive effector Rsp3 (repetitive secreted protein 3), which shows length polymorphisms in field isolates and is highly expressed during biotrophic stages. Rsp3 is required for virulence and anthocyanin accumulation. During biotrophic growth, Rsp3 decorates the hyphal surface and interacts with at least two secreted maize DUF26-domain family proteins (designated AFP1 and AFP2). AFP1 binds mannose and displays antifungal activity against the rsp3 mutant but not against a strain constitutively expressing rsp3. Maize plants silenced for AFP1 and AFP2 partially rescue the virulence defect of rsp3 mutants, suggesting that blocking the antifungal activity of AFP1 and AFP2 by the Rsp3 effector is an important virulence function. Rsp3 orthologs are present in all sequenced smut fungi, and the ortholog from Sporisorium reilianum can complement the rsp3 mutant of U. maydis, suggesting a novel widespread fungal protection mechanism.
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