Evidence map›Paper›PMID 29703847›Full record

ArticleBMJ open2018

Evaluating the long-term consequences of air pollution in early life: geographical correlations between coal consumption in 1951/1952 and current mortality in England and Wales.

David I W Phillips, Clive Osmond, Humphrey Southall, Paula Aucott, Alexander Jones, Stephen T Holgate

Abstract read
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Early Origins of Chronic Obstructive Pulmonary Disease: Prenatal and Early Life Risk Factors.International journal of environmental research and public health · 2023
    Review
  4. The "Cairo Accord"- Towards the Eradication of RHD: An Update.Frontiers in cardiovascular medicine · 2021
    Review
  5. THE EXPOSOME IN HUMAN EVOLUTION: FROM DUST TO DIESEL.The Quarterly review of biology · 2019
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David I W PhillipsThe Medical Research Council's Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Clive OsmondThe Medical Research Council's Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Humphrey SouthallDepartment of Geography, University of Portsmouth, Portsmouth, UK.
Paula AucottDepartment of Geography, University of Portsmouth, Portsmouth, UK.
Alexander JonesDepartment of Paediatrics, University of Oxford, Oxford, UK.
Stephen T HolgateDepartment of Medicine, University of Southampton, Southampton, UK.

Funding

British Heart Foundation FS/18/22/33479Medical Research Council G0400519Medical Research Council G0800766Medical Research Council MC_U147574242Medical Research Council MC_UP_A620_1016Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_12011/3Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

objectiveTo evaluate associations between early life air pollution and subsequent mortality.

designGeographical study.

settingLocal government districts within England and Wales. EXPOSURE: Routinely collected geographical data on the use of coal and related solid fuels in 1951-1952 were used as an index of air pollution.

main outcome measuresWe evaluated the relationship between these data and both all-cause and disease-specific mortality among men and women aged 35-74 years in local government districts between 1993 and 2012.

resultsDomestic (household) coal consumption had the most powerful associations with mortality. There were strong correlations between domestic coal use and all-cause mortality (relative risk per SD increase in fuel use 1.124, 95% CI 1.123 to 1.126), and respiratory (1.238, 95% CI 1.234 to 1.242), cardiovascular (1.138, 95% CI 1.136 to 1.140) and cancer mortality (1.073, 95% CI 1.071 to 1.075). These effects persisted after adjustment for socioeconomic indicators in 1951, current socioeconomic indicators and current pollution levels.

conclusionCoal was the major cause of pollution in the UK until the Clean Air Act of 1956 led to a rapid decline in consumption. These data suggest that coal-based pollution, experienced over 60 years ago in early life, affects human health now by increasing mortality from a wide variety of diseases.

Indexed as

Air PollutionCoalMortalityAdultAgedAir PollutantsEnglandFemaleHumansMaleMiddle AgedUnited KingdomWalesAir PollutantsCoalair pollutiondevelopmental origins of health and diseaseemortality

Identifiers

PMID29703847
PMCPMC5922482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.