ArticleDiabetes2018
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
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Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
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114citing papers in PubMed, 7 pooled it
14.5field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
114 citing papers in PubMed, 7 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- Genetic Risk Scores Identify People at High Risk of Developing Diabetic Kidney Disease: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2024Pooled it
- Association between the MCP-1 -2518 A > G (rs1024611) polymorphism and susceptibility to type 2 diabetes mellitus and diabetic nephropathy: a meta-analysis.BMC endocrine disorders · 2023Pooled it
- Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis.Human genomics · 2022Pooled it
- Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.Diabetologia · 2022Pooled it
- Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.Communications biology · 2022Pooled it
- Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.Genome medicine · 2018Pooled it
- A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.PloS one · 2018Pooled it
- Causal relationships between the gut microbiota, immune cells, and diabetic kidney disease: a Mendelian randomization and mediation analysis.Renal failure · 2026Article
- Prevalence of diagnostic Mendelian kidney disease variants in type 2 diabetes with and without diabetic kidney disease.Journal of diabetes investigation · 2026Article
- Genetic Determinants of Microvascular Complications of Type 1 Diabetes Mellitus: New Data from a Replication Study.Biomedicines · 2026Article
- Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes.Diabetologia · 2026Article
- From mechanisms to therapies: exploiting epigenetic and post-translational modifications of mitochondrial quality control in diabetic kidney disease.Frontiers in endocrinology · 2026Review
- Exome-Wide Analysis Identifies a RareKidney international reports · 2026Article
- Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy.Genome medicine · 2025Article
- Dietary habits and risk of diabetic kidney disease: a two-sample and multivariate Mendelian randomization study.Renal failure · 2025Article
- Regional autozygosity association with albumin-to-creatinine ratio reveals a novel FTO region in an Indigenous Australian population.European journal of human genetics : EJHG · 2025Article
- The impact of leisure sedentary behaviors on risk of chronic kidney disease, diabetes, and related complications: Mendelian randomization study.Renal failure · 2025Article
- Causal effects of gut microbiota on diabetic kidney disease: insights from 16S rRNA sequencing and bidirectional Mendelian randomization.Renal failure · 2025Article
- Impact of onset age of type 2 diabetes mellitus on risk of renal complications compared to age-matched non-diabetic patients: Two cohort studies in the United Kingdom and Hong Kong.Diabetes, obesity & metabolism · 2025Article
- Heterogeneity in the development of diabetes-related complications: narrative review of the roles of ancestry and geographical determinants.Diabetologia · 2025Review
54 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
87 authors at 20 institutions in 15 countries.
Natalie R van ZuydamWellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K. nvanzuy@well.ox.ac.uk.ORCID 0000-0002-9809-1398
Emma AhlqvistDiabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Niina SandholmFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.ORCID 0000-0003-4322-6942
Harshal DeshmukhNewcastle University, Newcastle, U.K.
N William RaynerWellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Moustafa AbdallaWellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Claes LadenvallDiabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Daniel ZiemekInflammation and Immunology Research Unit, Pfizer, Berlin, Germany.
Eric FaumanComputational Target Validation, Pfizer, Cambridge, MA.
Neil R RobertsonWellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Paul M McKeigueUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, U.K.
Erkka ValoFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Carol ForsblomFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Valma HarjutsaloFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Finnish Diabetic Nephropathy Study (FinnDiane)
Annalisa PernaClinical Research Center for Rare Diseases "Aldo e Cele Daccò," Istituto di Ricerche Farmacologiche "Mario Negri," Bergamo, Italy.
Erica RuraliClinical Research Center for Rare Diseases "Aldo e Cele Daccò," Istituto di Ricerche Farmacologiche "Mario Negri," Bergamo, Italy.
M Loredana MarcovecchioDepartment of Paediatrics, University of Cambridge, Cambridge, U.K.
Robert P IgoDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH.
Rany M SalemDepartment of Family Medicine and Public Health, University of California, San Diego, San Diego, CA.
Norberto PericoClinical Research Center for Rare Diseases "Aldo e Cele Daccò," Istituto di Ricerche Farmacologiche "Mario Negri," Bergamo, Italy.
Maria LajerSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Annemari KäräjämäkiDepartment of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.
Minako ImamuraDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Atsushi TakahashiDepartment of Genomic Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Jianjun LiuSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Guozhi JiangDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Claudia H T TamDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Andrea O Y LukDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Heung Man LeeDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Cadmon K P LimDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Cheuk Chun SzetoDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Wing Yee SoDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Juliana C N ChanDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Hong Kong Diabetes Registry Theme-based Research Scheme Project Group
Su Fen AngClinical Research Unit, Khoo Teck Puat Hospital, National Healthcare Group, Singapore.
Rajkumar DorajooDivision of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.
Ling WangDivision of Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.
Tan Si Hua ClaraClinical Research Unit, Khoo Teck Puat Hospital, National Healthcare Group, Singapore.
Amy-Jayne McKnightCentre for Public Health, Queen's University Belfast, Belfast, U.K.
Seamus DuffyCentre for Public Health, Queen's University Belfast, Belfast, U.K.
Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group
Marcus G PezzolesiDivision of Nephrology and Hypertension and Diabetes & Metabolism Research Center, University of Utah Health, Salt Lake City, UT.
GENIE (GEnetics of Nephropathy an International Effort) Consortium
Michel MarreSorbonnes Université, University Pierre and Marie Curie, INSERM UMRS 1166, Institute for Cardiometabolism and Nutrition, Department of Genomics and Pathophysiology of Cardiovascular Diseases, Paris, France.
Beata GyorgySorbonnes Université, University Pierre and Marie Curie, INSERM UMRS 1166, Institute for Cardiometabolism and Nutrition, Department of Genomics and Pathophysiology of Cardiovascular Diseases, Paris, France.
Samy HadjadjEndocrinology-Diabetology, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.
Linda T HirakiGenetics & Genome Biology, The Hospital for Sick Children, Toronto, Canada.
Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Peter AlmgrenDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Christina-Alexandra SchulzDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Marju Orho-MelanderDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Allan LinnebergResearch Centre for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark.
Cramer ChristensenDepartment of Internal Medicine and Endocrinology, Vejle Hospital, Vejle, Denmark.
Daniel R WitteDepartment of Public Health, Aarhus University, Aarhus, Denmark.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ivan BrandslundDepartment of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Olle MelanderHypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Andrew D PatersonGenetics & Genome Biology, The Hospital for Sick Children, Toronto, Canada.
David TregouetSorbonnes Université, University Pierre and Marie Curie, INSERM UMRS 1166, Institute for Cardiometabolism and Nutrition, Department of Genomics and Pathophysiology of Cardiovascular Diseases, Paris, France.
Alexander P MaxwellCentre for Public Health, Queen's University Belfast, Belfast, U.K.
Su Chi LimDiabetes Centre, Clinical Research Unit, Department of Medicine, Khoo Teck Puat Hospital, National Healthcare Group, Singapore.
Ronald C W MaDepartment of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Shiro MaedaDepartment of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Valeriya LyssenkoDiabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Tiinamaija TuomiFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Andrzej S KrolewskiJoslin Diabetes Center, Harvard Medical School, Boston, MA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.
Joel N HirschhornCenter for Basic and Translational Obesity Research and Division of Endocrinology, Boston Children's Hospital, Boston, MA.
Jose C FlorezPrograms in Medical and Population Genetics and Metabolism, Broad Institute, Cambridge, MA.
David DungerDepartment of Paediatrics, University of Cambridge, Cambridge, U.K.ORCID 0000-0002-2566-9304
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Peter RossingSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Giuseppe RemuzziClinical Research Center for Rare Diseases "Aldo e Cele Daccò," Istituto di Ricerche Farmacologiche "Mario Negri," Bergamo, Italy.
SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium
Mary Julia BrosnanCardiovascular, Metabolic and Endocrine Diseases Research Unit, Pfizer, Cambridge, MA.
Colin N A PalmerPat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, U.K.
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.ORCID 0000-0003-4055-6954
Helen M ColhounInstitute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, U.K.ORCID 0000-0002-8345-3288
Leif C GroopDiabetes and Endocrinology, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Mark I McCarthyWellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
Chinese University of Hong Kong · HKUniversity of Helsinki · FICentre for Human Genetics · GBMario Negri Institute for Pharmacological Research · ITLund University · SEUniversity of Cambridge · GBQueen's University Belfast · GBUniversity of Copenhagen · DKAgency for Science, Technology and Research · SGAarhus University · DKSteno Diabetes Centers · DKVaasa Central Hospital · FIBroad Institute · USInserm · FRNational University of Singapore · SGHelsinki University Hospital · FIKhoo Teck Puat Hospital · SGNinewells Hospital · GBPfizer (United States) · USCase Western Reserve University · US
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MVector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MIntegrative genomic, epigenetic and functional studies in diabetic kidney diseaseR01DK105154 · NIDDK · BROAD INSTITUTE, INC. · PI FLOREZ, JOSE CARLOS, HIRSCHHORN, JOEL N · 2016 to 2019
$3.0MMethods for high-resolution analysis of genetic effects on gene expressionR01MH101814 · NIMH · UNIVERSITY OF GENEVA · PI BUSTAMANTE, CARLOS DANIEL, DERMITZAKIS, EMMANOUIL · 2013 to 2016
$2.3MMethods for Genetic Association Analysis of Longitudinal and Multiple PhenotypesR00HL122515 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALEM, RANY · 2017 to 2019
$732kAustrian Science Fund FWF T 974Medical Research Council MC_PC_15025NHLBI NIH HHS R00 HL122515NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK105154NIMH NIH HHS R01 MH101814Wellcome TrustWellcome Trust 072960/Z/03/ZWellcome Trust 084726/Z/08/ZWellcome Trust 084727/Z/08/ZWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/ZWellcome Trust 090532Wellcome Trust 098381Wellcome Trust 106310
Abstract
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near
Indexed as
AdultAgedAged, 80 and overCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansKidney Failure, ChronicMaleMiddle AgedPolymorphism, Single NucleotideRenal Insufficiency, Chronic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.