ArticleThe Journal of biological chemistry2018
Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- From Genes to Gonads: Molecular Control Points of Reproduction in the Sea Urchin as a Framework for Aquaculture.International journal of molecular sciences · 2026Review
- Exploring the Utility of ALDH1 as a Marker for the Cancer Stem Cell Population in OCCC Cell Lines.Cells · 2026Article
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases.Military Medical Research · 2025Review
- The Three-Dimensional Structure of the Genome of the Dark Septate EndophyteJournal of fungi (Basel, Switzerland) · 2025Article
- A genetically encoded tool to increase cellular NADH/NADNature chemical biology · 2024Article
- Identification and Interpretation of eQTL and eGenes for Hodgkin Lymphoma Susceptibility.Genes · 2023Article
- Kynurenine Pathway Regulation at Its Critical Junctions with Fluctuation of Tryptophan.Metabolites · 2023Article
- Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature.International journal of molecular sciences · 2023Review
- Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention.International journal of molecular sciences · 2022Review
- Sexual Crossing, Chromosome-Level Genome Sequences, and Comparative Genomic Analyses for the Medicinal MushroomMicrobiology spectrum · 2022Article
- Review
- Review
- Twists and Turns in the Salicylate Catabolism ofmSystems · 2021Article
- Article
- Kynurenine pathway, NADExperimental gerontology · 2020Review
- Quaternary structure of α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase (ACMSD) controls its activity.The Journal of biological chemistry · 2019Article
- Retinoic acid signaling pathways.Development (Cambridge, England) · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The kynurenine pathway is the primary route for l-tryptophan degradation in mammals. Intermediates and side products of this pathway are involved in immune response and neurodegenerative diseases. This makes the study of enzymes, especially those from mammalian sources, of the kynurenine pathway worthwhile. Recent studies on a bacterial version of an enzyme of this pathway, 2-aminomuconate semialdehyde (2-AMS) dehydrogenase (AMSDH), have provided a detailed understanding of the catalytic mechanism and identified residues conserved for muconate semialdehyde recognition and activation. Findings from the bacterial enzyme have prompted the reconsideration of the function of a previously identified human aldehyde dehydrogenase, ALDH8A1 (or ALDH12), which was annotated as a retinal dehydrogenase based on its ability to preferentially oxidize 9-
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