Evidence map›Paper›PMID 29703727›Full record

ArticleHaematologica2018

NKG2D-based chimeric antigen receptor therapy induced remission in a relapsed/refractory acute myeloid leukemia patient.

David A Sallman, Jason Brayer, Elizabeth M Sagatys, Caroline Lonez, Eytan Breman, Sophie Agaugué, Bikash Verma, David E Gilham, Frédéric F Lehmann, Marco L Davila

Open access · goldAbstract readCase Reports
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pediatric AML CAR T cell therapy.Molecular therapy. Oncology · 2026
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  9. Cancer Nano-Immunotherapy: The Novel and Promising Weapon to Fight Cancer.International journal of molecular sciences · 2024
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

David A SallmanMalignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA David.Sallman@moffitt.org Marco.Davila@moffitt.org.
Jason BrayerMalignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Elizabeth M SagatysHematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Caroline LonezCelyad, SA, Mont-Saint-Guibert, Belgium.
Eytan BremanCelyad, SA, Mont-Saint-Guibert, Belgium.
Sophie AgauguéCelyad, SA, Mont-Saint-Guibert, Belgium.
Bikash VermaCelyad, SA, New York, NY, USA.
David E GilhamCelyad, SA, Mont-Saint-Guibert, Belgium.
Frédéric F LehmannCelyad, SA, Mont-Saint-Guibert, Belgium.
Marco L DavilaBlood & Marrow Transplantation and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA David.Sallman@moffitt.org Marco.Davila@moffitt.org.
Celyad (Belgium) · BEMoffitt Cancer Center · US

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunotherapy, AdoptiveBiomarkers, TumorBiopsyBone MarrowDrug Resistance, NeoplasmHumansImmunohistochemistryLeukemia, Myeloid, AcuteMaleMiddle AgedNK Cell Lectin-Like Receptor Subfamily KReceptors, Antigen, T-CellReceptors, Chimeric AntigenRecurrenceRemission InductionT-LymphocytesBiomarkers, TumorKLRK1 protein, humanNK Cell Lectin-Like Receptor Subfamily KReceptors, Antigen, T-CellReceptors, Chimeric Antigen

Identifiers

PMID29703727
PMCPMC6119132
OpenAlexW2802646364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.