Evidence map›Paper›PMID 29703391›Full record

ReviewJournal of food and drug analysis2018

Effects of processing adjuvants on traditional Chinese herbs.

Lin-Lin Chen, Robert Verpoorte, Hung-Rong Yen, Wen-Huang Peng, Yung-Chi Cheng, Jung Chao, Li-Heng Pao

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of food and drug analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Lin-Lin ChenKey Laboratory of Traditional Chinese Medicine Resource and Compound Prescription, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, China.
Robert VerpoorteNatural Products Laboratory, Institute of Biology, Leiden University, Leiden, The Netherlands.
Hung-Rong YenDepartment of Chinese Medicine, Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung, School of Chinese Medicine, Chinese Medicine Research Center, China Medical University, Taichung, Department of Biotechnology, Asia University, Taiwan.
Wen-Huang PengDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
Yung-Chi ChengDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
Jung ChaoChinese Medicine Research Center, Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan. Electronic address: jungchao1983@gmail.com.
Li-Heng PaoGraduate Institute of Health Industry Technology, Research Center for Food and Cosmetic Safety, and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address: paolhaa@gmail.com.
China Medical University · TWChang Gung University of Science and Technology · TWChina Medical University Hospital · TWHubei University of Chinese Medicine · CNLeiden University · NLYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude drugs. Proper processing is essential to ensure the quality and safety of traditional Chinese medicines (TCMs). Therefore, sound knowledge of processing principles is crucial to the standardized use of these processing adjuvants and to facilitate the production and clinical use of decoction pieces. Many scientific reports have indicated the synergistic effects of processing mechanisms on the chemistry, pharmacology, and pharmacokinetics of the active ingredients in TCMs. Under certain conditions, adjuvants change the content of active or toxic components in drugs by chemical or physical transformation, increase or decrease drug dissolution, exert their own pharmacological effects, or alter drug pharmacokinetics. This review summarizes various processing methods adopted in the last two decades, and highlights current approaches to identify the effects of processing parameters on TCMs.

Indexed as

Adjuvants, PharmaceuticAnimalsDrug CompoundingDrugs, Chinese HerbalHumansMedicine, Chinese TraditionalAdjuvants, PharmaceuticDrugs, Chinese HerbalAdjuvantProcessingSynergismTraditional Chinese medicine

Identifiers

PMID29703391
PMCPMC9326876
OpenAlexW2789905272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.