ArticleVirology journal2018
Zika virus-induced hyper excitation precedes death of mouse primary neuron.
Article in Virology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Herpes simplex virus pUL56 abolishes neuronal activity by removing voltage-gated ion channels from the plasma membrane.Science advances · 2026Article
- Pharmacological targeting of bunyavirus-induced synaptic impairment prevents neuronal hyperexcitability.Nature communications · 2026Article
- Review
- SARS-CoV-2-induced damage to rat cortical neuronal networks ex vivo is mediated by the pro-inflammatory activation of the cGAS-STING pathway.Journal of neurovirology · 2025Article
- The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection.Immunity · 2025Article
- Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG.Scientific reports · 2025Article
- FlightTrackAI: a robust convolutional neural network-based tool for tracking the flight behaviour ofRoyal Society open science · 2024Article
- RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during CNS viral infection.bioRxiv : the preprint server for biology · 2024Article
- Flight behaviour monitoring and quantification of aedes aegypti using convolution neural network.PloS one · 2023Article
- Astrocytes derived from neural progenitor cells are susceptible to Zika virus infection.PloS one · 2023Article
- β-Catenin Restricts Zika Virus Internalization by Downregulating Axl.Journal of virology · 2021Article
- Respiratory syncytial virus infection of microglia exacerbates SH-SY5Y neuronal cell injury by inducing the secretion of inflammatory cytokines: A TranswellIranian journal of basic medical sciences · 2021Article
- Article
- Zika Virus Infection in the Developing Mouse Produces Dramatically Different Neuropathology Dependent on Viral Strain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Compatibility Evaluation of Clustering Algorithms for Contemporary Extracellular Neural Spike Sorting.Frontiers in systems neuroscience · 2020Article
- Transcriptomic Analysis ofInternational journal of molecular sciences · 2019Article
- Genome-wide CRISPR screen for Zika virus resistance in human neural cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death.Cell death & disease · 2019Article
- Cryopreservation of Canine Primary Dorsal Root Ganglion Neurons and Its Impact upon Susceptibility to Paramyxovirus Infection.International journal of molecular sciences · 2019Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundZika virus infection in new born is linked to congenital syndromes, especially microcephaly. Studies have shown that these neuropathies are the result of significant death of neuronal progenitor cells in the central nervous system of the embryo, targeted by the virus. Although cell death via apoptosis is well acknowledged, little is known about possible pathogenic cellular mechanisms triggering cell death in neurons.
methodsWe used in vitro embryonic mouse primary neuron cultures to study possible upstream cellular mechanisms of cell death. Neuronal networks were grown on microelectrode array and electrical activity was recorded at different times post Zika virus infection. In addition to this method, we used confocal microscopy and Q-PCR techniques to observe morphological and molecular changes after infection.
resultsZika virus infection of mouse primary neurons triggers an early spiking excitation of neuron cultures, followed by dramatic loss of this activity. Using NMDA receptor antagonist, we show that this excitotoxicity mechanism, likely via glutamate, could also contribute to the observed nervous system defects in human embryos and could open new perspective regarding the causes of adult neuropathies.
conclusionsThis model of excitotoxicity, in the context of neurotropic virus infection, highlights the significance of neuronal activity recording with microelectrode array and possibility of more than one lethal mechanism after Zika virus infection in the nervous system.
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