ArticleBMC genomics2018
Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Natural genetic variation in wild-derived mice controls host survival and transcriptional responses during endotoxic shock.ImmunoHorizons · 2025Article
- Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300.PLoS genetics · 2024Article
- Strategies for generating mouse model resources of human disease.Protein & cell · 2023Article
- Using the collaborative cross to identify the role of host genetics in defining the murine gut microbiome.Microbiome · 2023Article
- Identification of collaborative cross mouse strains permissive to Salmonella enterica serovar Typhi infection.Scientific reports · 2023Article
- Transcriptome and proteome profile of jejunum in chickens challenged withFrontiers in microbiology · 2023Article
- Using the Collaborative Cross and Diversity Outbred Mice in Immunology.Current protocols · 2022Article
- Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.PLoS genetics · 2022Article
- Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing.Genetics · 2022Article
- These Are the Genes You're Looking For: Finding Host Resistance Genes.Trends in microbiology · 2021Review
- Host genetic control of natural killer cell diversity revealed in the Collaborative Cross.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Endosymbiotic RNA virus inhibitsiScience · 2021Article
- Article
- A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently ofJournal of virology · 2020Article
- A Loss-of-Function Mutation in the Integrin Alpha L (Infection and immunity · 2019Article
- Mouse Models as Resources for Studying Infectious Diseases.Clinical therapeutics · 2019Review
- Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse.Chemical research in toxicology · 2019Article
- Whole Genome Sequencing and Progress Toward Full Inbreeding of the Mouse Collaborative Cross Population.G3 (Bethesda, Md.) · 2019Article
- The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions.Cell host & microbe · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundSalmonella is a Gram-negative bacterium causing a wide range of clinical syndromes ranging from typhoid fever to diarrheic disease. Non-typhoidal Salmonella (NTS) serovars infect humans and animals, causing important health burden in the world. Susceptibility to salmonellosis varies between individuals under the control of host genes, as demonstrated by the identification of over 20 genetic loci in various mouse crosses. We have investigated the host response to S. Typhimurium infection in 35 Collaborative Cross (CC) strains, a genetic population which involves wild-derived strains that had not been previously assessed.
resultsOne hundred and forty-eight mice from 35 CC strains were challenged intravenously with 1000 colony-forming units (CFUs) of S. Typhimurium. Bacterial load was measured in spleen and liver at day 4 post-infection. CC strains differed significantly (P < 0.0001) in spleen and liver bacterial loads, while sex and age had no effect. Two significant quantitative trait loci (QTLs) on chromosomes 8 and 10 and one suggestive QTL on chromosome 1 were found for spleen bacterial load, while two suggestive QTLs on chromosomes 6 and 17 were found for liver bacterial load. These QTLs are caused by distinct allelic patterns, principally involving alleles originating from the wild-derived founders. Using sequence variations between the eight CC founder strains combined with database mining for expression in target organs and known immune phenotypes, we were able to refine the QTLs intervals and establish a list of the most promising candidate genes. Furthermore, we identified one strain, CC042/GeniUnc (CC042), as highly susceptible to S. Typhimurium infection.
conclusionsBy exploring a broader genetic variation, the Collaborative Cross population has revealed novel loci of resistance to Salmonella Typhimurium. It also led to the identification of CC042 as an extremely susceptible strain.
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Registered trials
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